Nanoscale Distribution of Transforming Growth Factor Receptor on Post-Golgi Vesicle Revealed by Super-resolution Microscopy
文献类型：期刊论文
| 作者 | Ruan, Hefei1,2; Yu, Jianqiang1; Yuan, Jinghe1; Li, Nan1,2; Fang, Xiaohong1,2 |
| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2016-12-06 |
| 卷号 | 11期号:23页码:3359-3364 |
| 关键词 | Clusters Receptors Stimulated Emission Depletion Microscopy Super-resolution Microscopy Vesicles |
| 英文摘要 | Transforming growth factor-beta (TGF-beta) type II receptor (T beta RII) plays a critical role in the initiation of TGF-beta signaling pathway; therefore, the study of its synthesis and transport processes is of great important. In this work, we achieved super-resolution imaging of a new type of T beta RII-containing post-Golgi vesicle by our home-built stimulated emission depletion (STED) microscope. We visualized the ring-shaped structure of these vesicles containing newly synthesized T beta RII in the cytoplasm and characterized their size distribution from 300 to 1000 nm. These vesicles could be swollen by chloroquine treatment. Further investigation revealed that T beta RII formed clusters on the outer ring of the post-Golgi vesicles. This study offers new information on the intracellular transportation of TGF-beta receptors for better understanding its signaling process. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38037]  |
| 专题 | 化学研究所_分子纳米结构与纳米技术实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, 2 ZhongGuanCun North First St, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ruan, Hefei,Yu, Jianqiang,Yuan, Jinghe,et al. Nanoscale Distribution of Transforming Growth Factor Receptor on Post-Golgi Vesicle Revealed by Super-resolution Microscopy[J]. CHEMISTRY-AN ASIAN JOURNAL,2016,11(23):3359-3364. |
| APA | Ruan, Hefei,Yu, Jianqiang,Yuan, Jinghe,Li, Nan,&Fang, Xiaohong.(2016).Nanoscale Distribution of Transforming Growth Factor Receptor on Post-Golgi Vesicle Revealed by Super-resolution Microscopy.CHEMISTRY-AN ASIAN JOURNAL,11(23),3359-3364. |
| MLA | Ruan, Hefei,et al."Nanoscale Distribution of Transforming Growth Factor Receptor on Post-Golgi Vesicle Revealed by Super-resolution Microscopy".CHEMISTRY-AN ASIAN JOURNAL 11.23(2016):3359-3364. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。