Injectable tissue adhesive composite hydrogel with fibroblasts for treating skin defects
文献类型：期刊论文
| 作者 | Zhu, Feiyan1; Wang, Chen2; Yang, Saina2; Wang, Qian2; Liang, Fuxin2; Liu, Chenyang3; Qiu, Dong2; Qu, Xiaozhong1,2; Hu, Zhongbo1; Yang, Zhenzhong2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2017-04-07 |
| 卷号 | 5期号:13页码:2416-2424 |
| 英文摘要 | In this work, an injectable composite hydrogel was synthesized via a unique way of crosslinking glycol chitosan (GC) with silica nano-particles (SiNP) through non-chemical interactions, and was then applied as a kind of wound dressing. Gelation was achieved through the incorporation of SiNPs with the GC segments in aqueous solution, therefore strictly confining the movement of the solubilized polymer chains. Rheology tests showed that the sol-gel transition and the moduli of the hydrogel were influenced by the composition of the two components, the size of the nano-particles and the conformation of the polymers. Using such a strategy, tissue adhesion properties of GC were well-preserved in the GC/SiNP hydrogel and therefore it gains gluey properties toward biological tissues as demonstrated through the adhesion of two pieces of mouse skin, obtaining a lap-shear stretching force of ca. 90 kPa. This characteristic, together with the injectability, allowed the hydrogel to be administrated directly on the wound site and to fill the wound area. Meanwhile, the hydrogel also works as a carrier of protein and cells. The in situ encapsulation of fibroblasts enabled the promising properties of the GC/SiNP hydrogel to be used for treating full-thickness skin defects in a mouse model, resulting in the favorable growth of hair follicles and microvessels, hence reducing the risk of scar formation. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38104]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Engn Plast, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Feiyan,Wang, Chen,Yang, Saina,et al. Injectable tissue adhesive composite hydrogel with fibroblasts for treating skin defects[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(13):2416-2424. |
| APA | Zhu, Feiyan.,Wang, Chen.,Yang, Saina.,Wang, Qian.,Liang, Fuxin.,...&Yang, Zhenzhong.(2017).Injectable tissue adhesive composite hydrogel with fibroblasts for treating skin defects.JOURNAL OF MATERIALS CHEMISTRY B,5(13),2416-2424. |
| MLA | Zhu, Feiyan,et al."Injectable tissue adhesive composite hydrogel with fibroblasts for treating skin defects".JOURNAL OF MATERIALS CHEMISTRY B 5.13(2017):2416-2424. |
入库方式： OAI收割
来源：化学研究所
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