Serum Metabolomics of Burkitt Lymphoma Mouse Models
文献类型：期刊论文
| 作者 | Yang, Fengmin1; Du, Jie2; Zhang, Hong1; Ruan, Guorui3,4; Xiang, Junfeng1; Wang, Lixia1; Sun, Hongxia1; Guan, Aijiao1; Shen, Gang1; Liu, Yan1 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2017-01-27 |
| 卷号 | 12期号:1 |
| 英文摘要 | Burkitt lymphoma (BL) is a rare and highly aggressive type of non-Hodgkin lymphoma. The mortality rate of BL patients is very high due to the rapid growth rate and frequent systemic spread of the disease. A better understanding of the pathogenesis, more sensitive diagnostic tools and effective treatment methods for BL are essential. Metabolomics, an important aspect of systems biology, allows the comprehensive analysis of global, dynamic and endogenous biological metabolites based on their nuclear magnetic resonance (NMR) and mass spectrometry (MS). It has already been used to investigate the pathogenesis and discover new biomarkers for disease diagnosis and prognosis. In this study, we analyzed differences of serum metabolites in BL mice and normal mice by NMR-based metabolomics. We found that metabolites associated with energy metabolism, amino acid metabolism, fatty acid metabolism and choline phospholipid metabolism were altered in BL mice. The diagnostic potential of the metabolite differences was investigated in this study. Glutamate, glycerol and choline had a high diagnostic accuracy; in contrast, isoleucine, leucine, pyruvate, lysine, a-ketoglutarate, betaine, glycine, creatine, serine, lactate, tyrosine, phenylalanine, histidine and formate enabled the accurate differentiation of BL mice from normal mice. The discovery of abnormal metabolism and relevant differential metabolites may provide useful clues for developing novel, noninvasive approaches for the diagnosis and prognosis of BL based on these potential biomarkers. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38116]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Natl Lab Mol Sci,Ctr Mol Sci, Beijing, Peoples R China 2.JOINN Labs Inc, Beijing, Peoples R China 3.Peking Univ, Peoples Hosp, Beijing, Peoples R China 4.Peking Univ, Inst Hematol, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Fengmin,Du, Jie,Zhang, Hong,et al. Serum Metabolomics of Burkitt Lymphoma Mouse Models[J]. PLOS ONE,2017,12(1). |
| APA | Yang, Fengmin.,Du, Jie.,Zhang, Hong.,Ruan, Guorui.,Xiang, Junfeng.,...&Tang, Yalin.(2017).Serum Metabolomics of Burkitt Lymphoma Mouse Models.PLOS ONE,12(1). |
| MLA | Yang, Fengmin,et al."Serum Metabolomics of Burkitt Lymphoma Mouse Models".PLOS ONE 12.1(2017). |
入库方式： OAI收割
来源：化学研究所
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