Engineering a favourable osteogenic microenvironment by heparin mediated hybrid coating assembly and rhBMP-2 loading
文献类型：期刊论文
| 作者 | Tan, Haoqi1,2; Wang, Honglei1,2; Chai, Yanjun1,2; Yu, Yuanman1,2; Hong, Hua1,2; Yang, Fei3; Qu, Xue1,2; Liu, Changsheng1,2 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:19页码:11439-11447 |
| 英文摘要 | With the development of bone tissue engineering, it is a great challenge to fabricate a bioactive surface which can provide a favourable microenvironment for cell adhesion, migration and osteo-differentiation. Coating the as-prepared substrates with bioactive components is an effective method to induce osteogenesis. In this study, we designed a multi-layered hybrid coating containing hydroxyapatite nanoparticles, heparin and chitosan. Heparin is used to mediate the electrostatic assembly of hydroxylapatite nanoparticles with chitosan, as well as the subsequent recombinant human bone morphogenetic protein-2 (rhBMP-2) loading. Several independent pieces of evidence were provided to indicate the successful fabrication of the hybrid coating. Sustained release of rhBMP-2 by this coating was also achieved. The in vitro biological studies reveal that the hybrid coating system has excellent biocompatibility and can improve the osteo-differentiation especially for rhBMP-2 present on the coating surface. The results demonstrate that the proposed rhBMP-2 loaded hybrid coating can provide a favourable osteogenic microenvironment and has the potential to improve in situ bone repair due to its superior osteoconductivity as well as osteoinductivity. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38145]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Haoqi,Wang, Honglei,Chai, Yanjun,et al. Engineering a favourable osteogenic microenvironment by heparin mediated hybrid coating assembly and rhBMP-2 loading[J]. RSC ADVANCES,2017,7(19):11439-11447. |
| APA | Tan, Haoqi.,Wang, Honglei.,Chai, Yanjun.,Yu, Yuanman.,Hong, Hua.,...&Liu, Changsheng.(2017).Engineering a favourable osteogenic microenvironment by heparin mediated hybrid coating assembly and rhBMP-2 loading.RSC ADVANCES,7(19),11439-11447. |
| MLA | Tan, Haoqi,et al."Engineering a favourable osteogenic microenvironment by heparin mediated hybrid coating assembly and rhBMP-2 loading".RSC ADVANCES 7.19(2017):11439-11447. |
入库方式： OAI收割
来源：化学研究所
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