Chiral Primary Amine Catalyzed Asymmetric alpha-Benzylation with In Situ Generated ortho-Quinone Methides
文献类型：期刊论文
| 作者 | Zhu, Yunbo; Zhang, Wen-Zhao; Zhang, Long; Luo, Sanzhong |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2017 |
| 卷号 | 23期号:6页码:1253-1257 |
| 关键词 | Asymmetric Synthesis Chiral Primary Amine Lewis Bases O-quinone Methide B-ketocarbonyls |
| 英文摘要 | A dual activation strategy integrating primary amine catalysis and Lewis base activation has been developed for an asymmetric alpha-benzylation reaction. Enamines derived from b-ketocarbonyls could react effectively with in situ generated ortho-quinone methides under Lewis base activation in asymmetric alpha-benzylation of beta-ketocarbonyls and a-branched aldehydes. The approach enables the creation of acyclic all-carbon quaternary stereocenters with excellent enantioselectivities and good activity. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38195]  |
| 专题 | 化学研究所_分子识别与功能实验室 |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Yunbo,Zhang, Wen-Zhao,Zhang, Long,et al. Chiral Primary Amine Catalyzed Asymmetric alpha-Benzylation with In Situ Generated ortho-Quinone Methides[J]. CHEMISTRY-A EUROPEAN JOURNAL,2017,23(6):1253-1257. |
| APA | Zhu, Yunbo,Zhang, Wen-Zhao,Zhang, Long,&Luo, Sanzhong.(2017).Chiral Primary Amine Catalyzed Asymmetric alpha-Benzylation with In Situ Generated ortho-Quinone Methides.CHEMISTRY-A EUROPEAN JOURNAL,23(6),1253-1257. |
| MLA | Zhu, Yunbo,et al."Chiral Primary Amine Catalyzed Asymmetric alpha-Benzylation with In Situ Generated ortho-Quinone Methides".CHEMISTRY-A EUROPEAN JOURNAL 23.6(2017):1253-1257. |
入库方式： OAI收割
来源：化学研究所
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