Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition
文献类型：期刊论文
| 作者 | Wang, Wenshuo1,3; Cui, Haijun1,3; Zhang, Pengchao2,3; Meng, Jingxin1; Zhang, Feilong2,3; Wang, Shutao1,3 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-03-29 |
| 卷号 | 9期号:12页码:10537-10543 |
| 关键词 | Biointerface Cancer Cell Recognition Topographic Interaction Cell Mineralization Hierarchical Structure |
| 英文摘要 | Cell-surface topographic interactions can direct the design of biointerfaces, which have been widely used in isolation of circulating tumor cells or fundamental cell biological research. By using three kinds of cancer cell-replicated surfaces with differentiated structures, we uncover that multiscale-cooperative topographic interactions (at both nanoscale and microscale) coupled with molecular recognition enable efficient and specific isolation of cancer cells. The cell replicas precisely inherit the structural features from the original cancer cells, providing not only preferable structures for matching with cancer cells but also a unique platform to interrogate whether certain cancer cells can optimally match with their own replicated surfaces. The results reveal that cancer cells do not show preferential recognitions to their respective replicas, while the capture agent-modified surfaces with hierarchical structures exhibit improved cancer cell capture efficiencies. Two levels of topographic interactions between cancer cells and cell replica surfaces exist. Nanoscale filopodia on cancer cells can topographically interact with different nanostructures on replica surfaces. In addition, microscale concave/convex on surfaces provide suitable sites for trapping cancer cells. This study may promote smart design of multiscale biofunctional materials that can specifically recognize cancer cells. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38240]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Nanosci, CAS Key Lab Bioinspired Mat & Interfacial Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Key Lab Organ Solids, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wenshuo,Cui, Haijun,Zhang, Pengchao,et al. Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(12):10537-10543. |
| APA | Wang, Wenshuo,Cui, Haijun,Zhang, Pengchao,Meng, Jingxin,Zhang, Feilong,&Wang, Shutao.(2017).Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition.ACS APPLIED MATERIALS & INTERFACES,9(12),10537-10543. |
| MLA | Wang, Wenshuo,et al."Efficient Capture of Cancer Cells by Their Replicated Surfaces Reveals Multiscale Topographic Interactions Coupled with Molecular Recognition".ACS APPLIED MATERIALS & INTERFACES 9.12(2017):10537-10543. |
入库方式： OAI收割
来源：化学研究所
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