Drug release kinetics from a drug-eluting stent with asymmetrical coat
文献类型：期刊论文
| 作者 | Zhang, Haijun1,2; Li, Xiaodong3; Deng, Wei4; Wang, Xiangfei2; Wang, Shenguo1,5; Ge, Junbo2; Toft, Egon1,6 |
| 刊名 | FRONTIERS IN BIOSCIENCE-LANDMARK
 |
| 出版日期 | 2017 |
| 卷号 | 22页码:407-415 |
| 关键词 | Biodegradable Polymer Drug-eluting Stent Drug Release Kinetics Sirolimus Paclitaxel |
| 英文摘要 | The aim of this study was to investigate the drug release profiles of biodegradable polymer sirolimus- or paclitaxel-eluting stents with asymmetrical coating (BPSES-A or BPPES-A) both in vitro and in vivo. In vitro, the drug release profile was characterized by measuring the drug concentration by HPLC over a time-course. In vivo, a porcine aorta stenting model was employed. The results showed that the drug release rates of BPSES-A and BPPES-A were slower, more stable and less burst releasing than those of conventionally coated stents (BPSES-C and BPPES-C respectively), both in vitro and in vivo. Based on the in vivo results, the sirolimus and paclitaxel content of the local coronary wall was maintained at a higher and more effective level with BPSES-A and BPPES-A than with BPSES-C and BPPES-C, respectively. The drug levels in peripheral tissue samples were below detection levels. These data demonstrated the effectiveness of both sirolimus and paclitaxel as stent coating agents, and revealed the favorable drug release kinetics and pharmacokinetics of asymmetrical coated stents compared with conventional coated stents. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38272]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Niels Jernes Vej, DK-109220 Aalborgo, Denmark 2.Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, 180 Fenglin Rd, Shanghai 200032, Peoples R China 3.China Med Univ, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Peoples R China 4.Fudan Univ, Sch Publ Hlth, Minist Educ, Key Lab Publ Hlth Safety, 130 Dongan Rd, Shanghai 200032, Peoples R China 5.Chinese Acad Sci, Inst Chem, Zhongguancun North First St 2, Beijing 100190, Peoples R China 6.Qatar Univ, Coll Med, Biomed Res Ctr, Postbox 2716, Doha, Qatar |
| 推荐引用方式 GB/T 7714 | Zhang, Haijun,Li, Xiaodong,Deng, Wei,et al. Drug release kinetics from a drug-eluting stent with asymmetrical coat[J]. FRONTIERS IN BIOSCIENCE-LANDMARK,2017,22:407-415. |
| APA | Zhang, Haijun.,Li, Xiaodong.,Deng, Wei.,Wang, Xiangfei.,Wang, Shenguo.,...&Toft, Egon.(2017).Drug release kinetics from a drug-eluting stent with asymmetrical coat.FRONTIERS IN BIOSCIENCE-LANDMARK,22,407-415. |
| MLA | Zhang, Haijun,et al."Drug release kinetics from a drug-eluting stent with asymmetrical coat".FRONTIERS IN BIOSCIENCE-LANDMARK 22(2017):407-415. |
入库方式： OAI收割
来源：化学研究所
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