A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity
文献类型：期刊论文
| 作者 | Wang, Bing1; Wang, Ming1; Mikhailovsky, Alexander1; Wang, Shu2; Bazan, Guillermo C.1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2017-04-24 |
| 卷号 | 56期号:18页码:5031-5034 |
| 关键词 | Biocidal Activity Conjugated Oligoelectrolyte Membrane Intercalating Photodynamic Antimicrobial Therapy |
| 英文摘要 | A membrane-intercalating conjugated oligoelectrolyte (COE), PTTP, was designed and synthesized with the goal of providing red-shifted absorption spectra relative to previously synthesized COE analogs. Specifically, electron-rich and electron-poor subunits were introduced in the conjugated backbone to modulate the band gap. PTTP exhibits maxima of absorption at 507 nm and of emission at 725 nm. PTTP can also efficiently function to generate singlet oxygen in situ (Phi(Delta) approximate to 20%) and has appropriate topology and dimensions to interact with lipid membranes. The resulting rapid membrane insertion and sensitizing ability provide PTTP with a highly efficient antibacterial capability under a low light dose (0.6 J cm(-2)) toward Gram-negative bacteria E. coli, making it a remarkably efficient optically mediated antimicrobial agent. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38345]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | 1.Univ Calif Santa Barbara, Ctr Polymers & Organ Solids, Dept Chem & Biochem, Santa Barbara, CA 93106 USA 2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Bing,Wang, Ming,Mikhailovsky, Alexander,et al. A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(18):5031-5034. |
| APA | Wang, Bing,Wang, Ming,Mikhailovsky, Alexander,Wang, Shu,&Bazan, Guillermo C..(2017).A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(18),5031-5034. |
| MLA | Wang, Bing,et al."A Membrane-Intercalating Conjugated Oligoelectrolyte with High-Efficiency Photodynamic Antimicrobial Activity".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.18(2017):5031-5034. |
入库方式： OAI收割
来源：化学研究所
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