Dopamine-assisted fixation of drug-loaded polymeric multilayers to osteoarticular implants for tuberculosis therapy
文献类型：期刊论文
| 作者 | Li, Dan1,2; Li, Litao3; Ma, Yunlong3; Zhuang, Yaping1,2; Li, Dawei3; Shen, Hong1; Wang, Xing1; Yang, Fei1,2; Ma, Yuanzheng3; Wu, Decheng1,2 |
| 刊名 | BIOMATERIALS SCIENCE
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 5期号:4页码:730-740 |
| 英文摘要 | Currently, the major issues in the treatment of osteoarticular tuberculosis (TB) after implant placement are low drug concentration at the infected focus and drug resistance resulting from the long-term chemotherapy. The application of drug-loaded polymeric multilayers on implantable devices offers a promising solution to the problems. Herein, a poly(ethylene glycol)-based hydrogel film embedded with isoniazid (INH)-loaded alginate microparticles was fixed to Ti implants via adhesive polydopamine, subsequently capped by poly(lactic-co-glycolic acid) membranes for the sustained and localized delivery of the anti-TB drug. The antibacterial efficacy of the released INH was confirmed by a 4.5 +/- 0.8 cm inhibition zone formed in the fourth week after inoculation of Mycobacterium tuberculosis. The INH-loaded Ti implants showed no toxicity to the osteoblast cell and provided a consistent drug release for nearly one week in vitro. The release profile in vivo showed a high local concentration and low systemic exposure. The local INH concentration could be kept higher than its minimum inhibitory concentration over a period of 8 weeks, which proves that it is a promising strategy to improve the severe osteoarticular TB treatment. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38347]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.309th Hosp PLA, Dept Orthopaed, Beijing 100094, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Dan,Li, Litao,Ma, Yunlong,et al. Dopamine-assisted fixation of drug-loaded polymeric multilayers to osteoarticular implants for tuberculosis therapy[J]. BIOMATERIALS SCIENCE,2017,5(4):730-740. |
| APA | Li, Dan.,Li, Litao.,Ma, Yunlong.,Zhuang, Yaping.,Li, Dawei.,...&Wu, Decheng.(2017).Dopamine-assisted fixation of drug-loaded polymeric multilayers to osteoarticular implants for tuberculosis therapy.BIOMATERIALS SCIENCE,5(4),730-740. |
| MLA | Li, Dan,et al."Dopamine-assisted fixation of drug-loaded polymeric multilayers to osteoarticular implants for tuberculosis therapy".BIOMATERIALS SCIENCE 5.4(2017):730-740. |
入库方式： OAI收割
来源：化学研究所
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