Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound
文献类型：期刊论文
| 作者 | Chen, Waner1,2,3,4; Yang, Yan1,2; Shangguan, Dihua5; Wu, Yuejing6; Liu, Zhe1,2,3,4 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:42页码:25892-25896 |
| 英文摘要 | Polymeric microbubbles bearing a hard shell exhibit prominent stability and tunable acoustical properties that serve the purposes of biomedical imaging and ultrasound (US)-triggered cavitations. It is of great significance to expand the utility scope of hard-shelled microbubbles withmultifunctionality, which will dramatically enhance the efficiency and precision of disease-oriented treatments. To this end, the multifunctional hard-shelled microbubbles (PMBs) for US imaging and US-triggered stimuli-responsive cavitations have been synthesized via a one-step in situ polymerization. Varied parameters including US frequency, acoustical powers and pulse duration time have been screened to optimize the cavitation conditions. It was notable to observe that by use of PMBs, a US-triggered progress of imaging, stable and inertial cavitations could be easily differentiated with an elaborately modulated parameter, which gives a visualizable pathway for imaging, stimuli-responsive cavitation, drug transportation and release at each stage. Meanwhile, commercial US contrast agents (Sonovue and Xueruixin with lipid and protein shell materials) have been compared with PMBs in terms of their cavitation performances. These valuable findings imply a promising perspective to use these multifunctional microbubbles as a novel visualizable theranostic strategy against diseases. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38425]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Ultrason Diag, Wenzhou 325027, Zhejiang, Peoples R China 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China 3.Wenzhou Med Univ, Wenzhou Inst Biomat & Engn, Wenzhou 325001, Zhejiang, Peoples R China 4.Chinese Acad Sci, Wenzhou Inst Biomat & Engn, Wenzhou 325011, Zhejiang, Peoples R China 5.Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem,Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 6.Tianjin First Ctr Hosp, Tianjin 300192, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Waner,Yang, Yan,Shangguan, Dihua,et al. Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound[J]. RSC ADVANCES,2017,7(42):25892-25896. |
| APA | Chen, Waner,Yang, Yan,Shangguan, Dihua,Wu, Yuejing,&Liu, Zhe.(2017).Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound.RSC ADVANCES,7(42),25892-25896. |
| MLA | Chen, Waner,et al."Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound".RSC ADVANCES 7.42(2017):25892-25896. |
入库方式： OAI收割
来源：化学研究所
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