Asymmetric hydroazidation of alpha-substituted vinyl ketones catalyzed by chiral primary amine
文献类型：期刊论文
| 作者 | Xue, Zai-Kun; Fu, Nian-Kai; Luo, San-Zhong |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2017-05-01 |
| 卷号 | 28期号:5页码:1083-1086 |
| 关键词 | Chiral Primary Amine Catalysis Hydroazidation Enamine Protonation Alpha-substituted Vinyl Ketones Aza-michael Addition Chiral Beta-azido Ketones |
| 英文摘要 | We report herein the first example of asymmetric hydroazidation of a-substituted vinyl ketones by using chiral primary amines as the catalysts. A simple chiral primary-tertiary diamine catalyst derived from phenylalanine was found to readily promote this aza-Michael addition reaction with enamine protonation as the key stereogenic step, thus enabling the effective synthesis of a-chiral beta-azido ketones with good yields and moderate enantioselectivities. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38484]  |
| 专题 | 化学研究所_分子识别与功能实验室 |
| 作者单位 | Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Zai-Kun,Fu, Nian-Kai,Luo, San-Zhong. Asymmetric hydroazidation of alpha-substituted vinyl ketones catalyzed by chiral primary amine[J]. CHINESE CHEMICAL LETTERS,2017,28(5):1083-1086. |
| APA | Xue, Zai-Kun,Fu, Nian-Kai,&Luo, San-Zhong.(2017).Asymmetric hydroazidation of alpha-substituted vinyl ketones catalyzed by chiral primary amine.CHINESE CHEMICAL LETTERS,28(5),1083-1086. |
| MLA | Xue, Zai-Kun,et al."Asymmetric hydroazidation of alpha-substituted vinyl ketones catalyzed by chiral primary amine".CHINESE CHEMICAL LETTERS 28.5(2017):1083-1086. |
入库方式： OAI收割
来源：化学研究所
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