Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells
文献类型：期刊论文
| 作者 | Yu, Ting-Ting1; Cui, Fu-Zhai2; Meng, Qing-Yuan2; Wang, Juan3,4; Wu, De-Cheng3,4; Zhang, Jin5; Kou, Xiao-Xing1; Yang, Rui-Li1; Liu, Yan1; Zhang, Yu Shrike5 |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2017-06-01 |
| 卷号 | 3期号:6页码:1119-1128 |
| 关键词 | Surface Chemistry Dental Pulp Stem Cells Adhesion Cell Fate Self-assembled Monolayer |
| 英文摘要 | The complex interaction between extracellular matrix and cells makes the design of materials for dental regeneration challenging. Chemical composition is an important characteristic of biomaterial surfaces, which plays an essential role in modulating the adhesion and function of cells. The effect of different chemical groups on directing the fate of human dental pulp stem cells (hDPSCs) was thus explored in our study. A range of self-assembled monolayers (SAMs) with amino (-NH2), hydroxyl (-OH), carboxyl (-COOH), and methyl (-CH3) modifications were prepared. Proliferation, morphology, adhesion, and differentiation of hDPSCs were then analyzed to demonstrate the effects of surface chemical groups. The results showed that hDPSCs attached to the -NH2 surface displayed a highly branched osteocytelike morphology with improved cell adhesion and proliferation abilities. Moreover, hDPSCs cultured on the -NH2 surface also tended to obtain an increased osteo/odontogenesis differentiation potential. However, the hDPSCs on the -COOH, -OH, and -CH3 surfaces preferred to maintain the mesenchymal stem cell-like phenotype. In summary, this study indicated the influence of chemical groups on hDPSCs in vitro and demonstrated that -NH2 might be a promising surface modification strategy to achieve improved biocompatibility, osteoconductivity/osteoinductivity, and osseointegration of dental implants, potentially facilitating dental tissue regeneration. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38921]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Dept Orthodont, Beijing 100081, Peoples R China 2.Tsinghua Univ, Sch Mat Sci & Engn, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA |
| 推荐引用方式 GB/T 7714 | Yu, Ting-Ting,Cui, Fu-Zhai,Meng, Qing-Yuan,et al. Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2017,3(6):1119-1128. |
| APA | Yu, Ting-Ting.,Cui, Fu-Zhai.,Meng, Qing-Yuan.,Wang, Juan.,Wu, De-Cheng.,...&Zhou, Yan-Heng.(2017).Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.ACS BIOMATERIALS SCIENCE & ENGINEERING,3(6),1119-1128. |
| MLA | Yu, Ting-Ting,et al."Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells".ACS BIOMATERIALS SCIENCE & ENGINEERING 3.6(2017):1119-1128. |
入库方式： OAI收割
来源：化学研究所
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