Metal-Free Direct Alkylation of Ketene Dithioacetals by Oxidative C(sp(2))-H/C(sp(3))-H Cross-Coupling
文献类型：期刊论文
| 作者 | Wen, Jiangwei1; Zhang, Fan1; Shi, Wenyan1; Lei, Aiwen1,2 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2017-07-03 |
| 卷号 | 23期号:37页码:8814-8817 |
| 关键词 | Alkylation C-h Activation Internal Olefins Metal-free Cross-coupling |
| 英文摘要 | The functionalization of internal olefins has been a challenging task in organic synthesis. This protocol provides an efficient and transition-metal-free direct oxidative C(sp(2))-H/C(sp(3))-H cross-coupling method to access tetrasubstituted olefins. The push-pull effect from the polarized olefin substrates accelerates the internal olefin C-H alkylation. Importantly, the mechanistic experimental results demonstrate that the alkanes C-H bond cleavage is the rate-determining step, and a radical pathway has been proposed for the alkylation reaction. Notably, the present protocol has excellent functional group tolerance and could be easily scaled up with good efficiency. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38930]  |
| 专题 | 化学研究所_分子识别与功能实验室 |
| 作者单位 | 1.Wuhan Univ, Coll Chem & Mol Sci, IAS, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognizat & Funct, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Jiangwei,Zhang, Fan,Shi, Wenyan,et al. Metal-Free Direct Alkylation of Ketene Dithioacetals by Oxidative C(sp(2))-H/C(sp(3))-H Cross-Coupling[J]. CHEMISTRY-A EUROPEAN JOURNAL,2017,23(37):8814-8817. |
| APA | Wen, Jiangwei,Zhang, Fan,Shi, Wenyan,&Lei, Aiwen.(2017).Metal-Free Direct Alkylation of Ketene Dithioacetals by Oxidative C(sp(2))-H/C(sp(3))-H Cross-Coupling.CHEMISTRY-A EUROPEAN JOURNAL,23(37),8814-8817. |
| MLA | Wen, Jiangwei,et al."Metal-Free Direct Alkylation of Ketene Dithioacetals by Oxidative C(sp(2))-H/C(sp(3))-H Cross-Coupling".CHEMISTRY-A EUROPEAN JOURNAL 23.37(2017):8814-8817. |
入库方式： OAI收割
来源：化学研究所
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