Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo
文献类型：期刊论文
| 作者 | Liu, Ying1,2; Hu, Xiaoxiao3,4; Wang, Linlin1,2; Liu, Xiangjun1,2; Bing, Tao1,2; Tan, Weihong3,4,5; Shangguan, Dihua1,2 |
| 刊名 | DYES AND PIGMENTS
 |
| 出版日期 | 2017-10-01 |
| 卷号 | 145页码:168-173 |
| 关键词 | Photodynamic Therapy Photosensitizers Quinacridone Derivatives Photo-toxicity Cancer |
| 英文摘要 | The lack of ideal photosensitizers is the major limitation for clinical photodynamic therapy (PDT). Quinacridone (QA) is a mass-produced industrial organic pigment. QA derivatives are widely investigated for many applications in various fields, but rarely involved in biological applications. Here we report the PDT effects of N,N'-bis(methylpiperazinylpentyl) QA (QAP) in cells and in vivo. QAP shows low dark -toxicity and high photo-toxicity in cells through generating reactive oxygen species (ROS) under irradiation; and greatly inhibits the tumor growth in a mouse subcutaneous xenograft model after irradiation with a 532 nm laser. The high photodynamic efficiency of QAP shows the great potential of QA derivatives to be a new class of leading compound of photosensitizers in PDT. (C) 2017 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38953]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Analyt Chem Living Biosyst, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Coll Life Sci, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China 4.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China 5.Univ Florida, Dept Chem, Ctr Res Bio Nano Interface, Hlth Canc Ctr,Genet Inst,McKnight Brain Inst, Gainesville, FL 32611 USA |
| 推荐引用方式 GB/T 7714 | Liu, Ying,Hu, Xiaoxiao,Wang, Linlin,et al. Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo[J]. DYES AND PIGMENTS,2017,145:168-173. |
| APA | Liu, Ying.,Hu, Xiaoxiao.,Wang, Linlin.,Liu, Xiangjun.,Bing, Tao.,...&Shangguan, Dihua.(2017).Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo.DYES AND PIGMENTS,145,168-173. |
| MLA | Liu, Ying,et al."Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo".DYES AND PIGMENTS 145(2017):168-173. |
入库方式： OAI收割
来源：化学研究所
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