Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging
文献类型：期刊论文
| 作者 | Wu, Kui1,2,3; Jia, Feifei1,2,3; Zheng, Wei1,2,3; Luo, Qun1,2,3,4; Zhao, Yao1,2,3; Wang, Fuyi1,2,3,4 |
| 刊名 | JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
 |
| 出版日期 | 2017-07-01 |
| 卷号 | 22期号:5页码:653-661 |
| 关键词 | Secondary Ion Mass Spectrometry Metallodrug Visualization Single Cell Mass Spectrometry Imaging |
| 英文摘要 | Secondary ion mass spectrometry, including nanoscale secondary ion mass spectrometry (NanoSIMS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), has emerged as a powerful tool for biological imaging, especially for single cell imaging. SIMS imaging can provide information on subcellular distribution of endogenous and exogenous chemicals, including metallodrugs, from membrane through to cytoplasm and nucleus without labeling, and with high spatial resolution and chemical specificity. In this mini-review, we summarize recent progress in the field of SIMS imaging, particularly in the characterization of the subcellular distribution of metallodrugs. We anticipate that the SIMS imaging method will be widely applied to visualize subcellular distributions of drugs and drug candidates in single cells, exerting significant influence on early drug evaluation and metabolism in medicinal and pharmaceutical chemistry. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38977]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Natl Ctr Mass Spectrometry Beijing, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Kui,Jia, Feifei,Zheng, Wei,et al. Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2017,22(5):653-661. |
| APA | Wu, Kui,Jia, Feifei,Zheng, Wei,Luo, Qun,Zhao, Yao,&Wang, Fuyi.(2017).Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,22(5),653-661. |
| MLA | Wu, Kui,et al."Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 22.5(2017):653-661. |
入库方式： OAI收割
来源：化学研究所
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