pH-Responsive self-assembly of cationic surfactants with a star-shaped tetra-carboxylate acid and the solubilization of hydrophobic drugs
文献类型：期刊论文
| 作者 | Qi, Ruilian1,2; Liu, Zhang1; Zhou, Chengcheng1,2; Han, Yuchun1; Wang, Yilin1,2 |
| 刊名 | SOFT MATTER
 |
| 出版日期 | 2017-11-14 |
| 卷号 | 13期号:42页码:7804-7812 |
| 英文摘要 | This work involved the construction of pH-responsive self-assembly systems from a pH-sensitive four-arm carboxylate acid (4EOCOOH) and either the cationic single chain surfactant dodecyl trimethyl ammonium bromide (DTAB) or the cationic gemini surfactant hexamethylene-1,6-bis(dodecyldimethylammonium bromide) (12-6-12). It was found that the constructed oligomeric-like structures from the mixtures of 4EOCOOH with DTAB or 12-6-12 greatly enhance the aggregation ability of the mixtures, thus improving the pH-responsivity. In particular, surfactant concentrations significantly affect the pH-responsivity at a fixed 4EOCOOH concentration. At higher surfactant concentrations, the pH-responsivity is suppressed, while at lower surfactant concentrations, the mixed aggregates gradually change from micelles to unstable large spherical aggregates or vesicles, and then to stable spherical aggregates, with decreasing pH. Moreover, the surfactant/4EOCOOH systems have different solubilization abilities for three hydrophobic drugs. For quercetin and baicalein, the systems support much better solubilization at lower pH values, while for indomethacin, the systems show better solubilization at higher pH values. In particular, compared with DTAB, 12-6-12 is more efficient in constructing pH-responsive systems, and the 12-6-12/4EOCOOH mixture shows better ability for solubilizing hydrophobic drugs. This work will be helpful in the design of high-efficiency, pH-responsive surfactant systems for solubilizing hydrophobic drugs by simply mixing pH-sensitive molecules with surfactants. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/39103]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Colloid Interface & Chem Thermodynam, BNLMS, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Ruilian,Liu, Zhang,Zhou, Chengcheng,et al. pH-Responsive self-assembly of cationic surfactants with a star-shaped tetra-carboxylate acid and the solubilization of hydrophobic drugs[J]. SOFT MATTER,2017,13(42):7804-7812. |
| APA | Qi, Ruilian,Liu, Zhang,Zhou, Chengcheng,Han, Yuchun,&Wang, Yilin.(2017).pH-Responsive self-assembly of cationic surfactants with a star-shaped tetra-carboxylate acid and the solubilization of hydrophobic drugs.SOFT MATTER,13(42),7804-7812. |
| MLA | Qi, Ruilian,et al."pH-Responsive self-assembly of cationic surfactants with a star-shaped tetra-carboxylate acid and the solubilization of hydrophobic drugs".SOFT MATTER 13.42(2017):7804-7812. |
入库方式： OAI收割
来源：化学研究所
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