Aromatic C-H addition of ketones to imines enabled by manganese catalysis
文献类型：期刊论文
| 作者 | Zhou, Bingwei1,2; Hu, Yuanyuan1,2; Liu, Ting1,2; Wang, Congyang1,2 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2017-10-27 |
| 卷号 | 8 |
| 英文摘要 | Selectivity control of varied C-H bonds in a complex molecule is a long-standing goal and still a great challenge in C-H activation field. Most often, such selectivity is achieved by the innate reactivity of different C-H bonds. In this context, the classic Mannich reaction of acetophenone derivatives and imines is ascribed to the more reactive C(sp(3))-H bonds a to the carbonyl, with the much less reactive aromatic C(sp(2))-H bonds remaining intact. Herein we report an aromatic C(sp(2))-H addition of ketones to imines enabled by manganese catalysis, which totally reverses the innate reactivity of C-H bonds a to the carbonyl and those on the aromatic ring. Diverse products of ortho-C-H aminoalkylated ketones, cyclized exo-olefinic isoindolines, and three-component methylated isoindolines can be successfully accessed under mild reaction conditions, which significantly expands the synthetic utilities of ketones as simple bulk chemicals. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/39123]  |
| 专题 | 化学研究所_分子识别与功能实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Bingwei,Hu, Yuanyuan,Liu, Ting,et al. Aromatic C-H addition of ketones to imines enabled by manganese catalysis[J]. NATURE COMMUNICATIONS,2017,8. |
| APA | Zhou, Bingwei,Hu, Yuanyuan,Liu, Ting,&Wang, Congyang.(2017).Aromatic C-H addition of ketones to imines enabled by manganese catalysis.NATURE COMMUNICATIONS,8. |
| MLA | Zhou, Bingwei,et al."Aromatic C-H addition of ketones to imines enabled by manganese catalysis".NATURE COMMUNICATIONS 8(2017). |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。