Esterification of Carboxylic Acids with Difluoromethyl Diazomethane and Interrupted Esterification with Trifluoromethyl Diazomethane: A Fluorine Effect
文献类型：期刊论文
| 作者 | Peng, Shan-Qing1; Zhang, Xiao-Wei1; Zhang, Long2; Hu, Xiang-Guo1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2017-10-20 |
| 卷号 | 19期号:20页码:5689-5692 |
| 英文摘要 | It is demonstrated that difluoromethyl diazomethane (HCF2CHN2) can react with a broad range of carboxylic acids. The reaction is convenient, operationally simple, mild, and tolerant of a variety of different functional groups. In sharp contrast, trifluoromethyl diazomethane (CF3CHN2) fails to react with carboxylic acids in most Solvents,, and in acetonitrile this reagent instead undergoes an interrupted esterification (a Mumm reaction) to yield N-trifluoroethyl imides. This striking example of the ability of a single F-for-H substitution to alter a reaction pathway was rationalized through a DFT study. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/39144]  |
| 专题 | 化学研究所_分子识别与功能实验室 |
| 作者单位 | 1.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Shan-Qing,Zhang, Xiao-Wei,Zhang, Long,et al. Esterification of Carboxylic Acids with Difluoromethyl Diazomethane and Interrupted Esterification with Trifluoromethyl Diazomethane: A Fluorine Effect[J]. ORGANIC LETTERS,2017,19(20):5689-5692. |
| APA | Peng, Shan-Qing,Zhang, Xiao-Wei,Zhang, Long,&Hu, Xiang-Guo.(2017).Esterification of Carboxylic Acids with Difluoromethyl Diazomethane and Interrupted Esterification with Trifluoromethyl Diazomethane: A Fluorine Effect.ORGANIC LETTERS,19(20),5689-5692. |
| MLA | Peng, Shan-Qing,et al."Esterification of Carboxylic Acids with Difluoromethyl Diazomethane and Interrupted Esterification with Trifluoromethyl Diazomethane: A Fluorine Effect".ORGANIC LETTERS 19.20(2017):5689-5692. |
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来源：化学研究所
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