Selective recognition of c-myc promoter G-quadruplex and down-regulation of oncogene c-myc transcription in human cancer cells by 3,8a-disubstituted indolizinone
文献类型：期刊论文
| 作者 | Yang, Fengmin1,2; Sun, Xin1; Wang, Lixia1; Li, Qian1; Guan, Aijiao1; Shen, Gang1,2; Tang, Yalin1,2 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:82页码:51965-51969 |
| 英文摘要 | C-myc promoter G-quadruplex is a very important target for developing anti-cancer drugs. However, highly selective recognition of DNA c-myc G-quadruplex with parallel configuration is also a very challenging problem. Here, we showed a new type of N-containing alkaloid, 3,8a-disubstituted indolizinone, which adopted a distorted configuration. 6-Methyl-3-(naphthalen-2-yl)-8a-(4methylpyridin- 2-yl)-indolizinone could selectively recognize DNA c-myc G-quadruplex leading to an obvious fluorescence enhancement by 11-fold, and meanwhile the G-quadruplex can be stabilized up to 90 degrees C. Further, it could down-regulate the transcription of oncogene c-myc in both human non-small cell line (A549) and human laryngeal epithelial cell line (Hep-2). |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/39150]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Natl Lab Mol Sci,Ctr Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Yuquan Rd 19 A, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Fengmin,Sun, Xin,Wang, Lixia,et al. Selective recognition of c-myc promoter G-quadruplex and down-regulation of oncogene c-myc transcription in human cancer cells by 3,8a-disubstituted indolizinone[J]. RSC ADVANCES,2017,7(82):51965-51969. |
| APA | Yang, Fengmin.,Sun, Xin.,Wang, Lixia.,Li, Qian.,Guan, Aijiao.,...&Tang, Yalin.(2017).Selective recognition of c-myc promoter G-quadruplex and down-regulation of oncogene c-myc transcription in human cancer cells by 3,8a-disubstituted indolizinone.RSC ADVANCES,7(82),51965-51969. |
| MLA | Yang, Fengmin,et al."Selective recognition of c-myc promoter G-quadruplex and down-regulation of oncogene c-myc transcription in human cancer cells by 3,8a-disubstituted indolizinone".RSC ADVANCES 7.82(2017):51965-51969. |
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来源：化学研究所
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