Effects of HAp and TCP in constructing tissue engineering scaffolds for bone repair
文献类型：期刊论文
| 作者 | Xu, Sijia1,2; Liu, Jianheng3; Zhang, Licheng3; Yang, Fei1,2; Tang, Peifu3; Wu, Decheng1,2 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2017-08-14 |
| 卷号 | 5期号:30页码:6110-6118 |
| 英文摘要 | In recent years, hydroxyapatite (HAp) and beta-tricalcium phosphate (TCP) were extensively used to prepare composite scaffolds for bone repair. However, due to a lack of systematical evaluation of HAp and TCP composite scaffolds for bone repair, their distinctions on bone regeneration in vivo have not been clearly clarified to date. In this study, we constructed HAp and TCP composite poly(lactic-co-glycolic acid) (PLGA) scaffolds with the same contents of HAp and TCP and similar structures and porosities, and systematically investigated their performance in the repair of rabbits' calvarial bone defects. The HAp/PLGA scaffold possessed stronger mechanical property and higher cell proliferation than the TCP/PLGA scaffold, endowing it with better performance of bone regeneration at an early stage. Since TCP could greatly neutralize degraded acidic products and be slowly absorbed in vivo to release occupied room for new bone growth compared to HAp, the TCP/PLGA scaffold yielded more intact new bone for long-term repair of the defects. Our results clearly demonstrate that TCP is a superior bioceramic for bone tissue engineering, showing promise for the perfect repair of bone defects via tissue engineering. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/39214]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Sijia,Liu, Jianheng,Zhang, Licheng,et al. Effects of HAp and TCP in constructing tissue engineering scaffolds for bone repair[J]. JOURNAL OF MATERIALS CHEMISTRY B,2017,5(30):6110-6118. |
| APA | Xu, Sijia,Liu, Jianheng,Zhang, Licheng,Yang, Fei,Tang, Peifu,&Wu, Decheng.(2017).Effects of HAp and TCP in constructing tissue engineering scaffolds for bone repair.JOURNAL OF MATERIALS CHEMISTRY B,5(30),6110-6118. |
| MLA | Xu, Sijia,et al."Effects of HAp and TCP in constructing tissue engineering scaffolds for bone repair".JOURNAL OF MATERIALS CHEMISTRY B 5.30(2017):6110-6118. |
入库方式： OAI收割
来源：化学研究所
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