Polarity Conversion of Conjugated Polymer for Lysosome Escaping
文献类型：期刊论文
| 作者 | Zhou, Lingyun1,2; Lv, Fengting1; Liu, Libing1; Wang, Shu1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-08-23 |
| 卷号 | 9期号:33页码:27427-27432 |
| 关键词 | Lysosome Escaping Conjugated Polymers Polarity Conversion Fluorescent Tracer Ph Response |
| 英文摘要 | Polymers are mostly trapped in lysosomes when they enter cells and are then expelled, otherwise they were:designed to be degradable to small molecules or to sabotage lysosomes. Therefore, they have reached the limit of the :unique functionalities as a whole. Different from other escaping:Strategies, we introduced the polarity exchanging approach to rigid-backboned conjugated polymer for ,controlled penetrating through endosome or lysosome membranes. With the aid of pH-sensitive cleavage of water-soluble side chain, the rigid conjugated polymer turns highly hydrophobic after it is internalized into lysosomes and then accomplishes escaping. Thus, polarity exchange of CPs could become a new strategy for their application on chemotherapeutics. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/39259]  |
| 专题 | 化学研究所_有机固体实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100910, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lingyun,Lv, Fengting,Liu, Libing,et al. Polarity Conversion of Conjugated Polymer for Lysosome Escaping[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(33):27427-27432. |
| APA | Zhou, Lingyun,Lv, Fengting,Liu, Libing,&Wang, Shu.(2017).Polarity Conversion of Conjugated Polymer for Lysosome Escaping.ACS APPLIED MATERIALS & INTERFACES,9(33),27427-27432. |
| MLA | Zhou, Lingyun,et al."Polarity Conversion of Conjugated Polymer for Lysosome Escaping".ACS APPLIED MATERIALS & INTERFACES 9.33(2017):27427-27432. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。