NIR Ratiometric Luminescence Detection of pH Fluctuation in Living Cells with Hemicyanine Derivative-Assembled Upconversion Nanophosphors
文献类型：期刊论文
| 作者 | Li, Haixia1; Dong, Hao2; Yu, Mingming1; Liu, Chunxia1; Li, Zhanxian1; Wei, Liuhe1; Sun, Ling-Dong2; Zhang, Hongyan3 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2017-09-05 |
| 卷号 | 89期号:17页码:8863-8869 |
| 英文摘要 | It is crucial for cell physiology to keep the homeostasis of pH, and it is highly demanded yet challenging to develop luminescence resonance energy transfer (LRET)-based near-infrared (NIR) ratiometric luminescent sensor for the detection of pH fluctuation with NIR excitation. As promising energy donors for LRET, upconversion nanoparticles (UCNPs) have been widely used to fabricate nanosensors, but the relatively low LRET efficiency limits their application in bioassay. To improve the LRET efficiency, core/shell/shell structured beta-NaGdF4@NaYF4:Yb,Tm@NaYF4 UCNPs were prepared and decorated with hemicyanine dyes as an LRET-based NIR ratiometric luminescent pH fluctuation-nanosensor for the first time. The as-developed nanosensor not only exhibits good antidisturbance ability, but it also can reversibly sense pH and linearly sense pH in a range of 6.0-9.0 and 6.8-9.0 from absorption and upconversion emission spectra, respectively. In addition, the nanosensor displays low dark toxicity under physiological temperature, indicating good biocompatibility. Furthermore, live cell imaging results revealed that the sensor can selectively monitor pH fluctuation via ratiometric upconversion luminescence behavior. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/41046]  |
| 专题 | 化学研究所_光化学实验室 |
| 作者单位 | 1.Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Che, Beijing Natl Lab Mol Sci,State Key Lab Rare Earth, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Haixia,Dong, Hao,Yu, Mingming,et al. NIR Ratiometric Luminescence Detection of pH Fluctuation in Living Cells with Hemicyanine Derivative-Assembled Upconversion Nanophosphors[J]. ANALYTICAL CHEMISTRY,2017,89(17):8863-8869. |
| APA | Li, Haixia.,Dong, Hao.,Yu, Mingming.,Liu, Chunxia.,Li, Zhanxian.,...&Zhang, Hongyan.(2017).NIR Ratiometric Luminescence Detection of pH Fluctuation in Living Cells with Hemicyanine Derivative-Assembled Upconversion Nanophosphors.ANALYTICAL CHEMISTRY,89(17),8863-8869. |
| MLA | Li, Haixia,et al."NIR Ratiometric Luminescence Detection of pH Fluctuation in Living Cells with Hemicyanine Derivative-Assembled Upconversion Nanophosphors".ANALYTICAL CHEMISTRY 89.17(2017):8863-8869. |
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来源：化学研究所
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