Covalent-reaction-induced interfacial assembly to transform doxorubicin into nanophotomedicine with highly enhanced anticancer efficiency
文献类型：期刊论文
| 作者 | Qin, Chenchen1,2; Fei, Jinbo1; Cui, Ganglong3; Liu, Xiangyang3; Fang, Weihai3; Yang, Xiaoke1,2; Liu, Xingcen1,2; Li, Junbai1,2 |
| 刊名 | PHYSICAL CHEMISTRY CHEMICAL PHYSICS
 |
| 出版日期 | 2017-09-21 |
| 卷号 | 19期号:35页码:23733-23739 |
| 英文摘要 | Herein, we show that a molecular assembly offers tremendous opportunities of affording existing building units with new physicochemical properties, holding promise in wide applications. Herein, we develop a facile covalent assembly using a natural occurring linker, genipin, to efficiently transform a traditional chemo drug, doxorubicin, into a nanophotomedicine. A possible mechanism is proposed, in which doxorubicin reacts with genipin through covalent bonding to produce poorly soluble units, which further form nuclei and mediate the interfacial assembly to generate uniform nanoparticles. Such assembled nanophotomedicine shows remarkably enhanced singlet oxygen generation ability (about 1000 folds), leading to a much higher photodynamic activity. Moreover, this self-carried nanodrug exhibits adjustable size, excellent colloidal stability, high capacity and preferable endocytosis. These favorable features lead to greatly improved anticancer efficiency under light at the same dosage, compared to that of pure doxorubin. We believe this study brings a new dimension to develop advanced drug delivery systems by molecular assembly. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/41067]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Normal Univ, Dept Chem Coll, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qin, Chenchen,Fei, Jinbo,Cui, Ganglong,et al. Covalent-reaction-induced interfacial assembly to transform doxorubicin into nanophotomedicine with highly enhanced anticancer efficiency[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2017,19(35):23733-23739. |
| APA | Qin, Chenchen.,Fei, Jinbo.,Cui, Ganglong.,Liu, Xiangyang.,Fang, Weihai.,...&Li, Junbai.(2017).Covalent-reaction-induced interfacial assembly to transform doxorubicin into nanophotomedicine with highly enhanced anticancer efficiency.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,19(35),23733-23739. |
| MLA | Qin, Chenchen,et al."Covalent-reaction-induced interfacial assembly to transform doxorubicin into nanophotomedicine with highly enhanced anticancer efficiency".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 19.35(2017):23733-23739. |
入库方式： OAI收割
来源：化学研究所
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