Tuning Antibacterial Activity of Cyclodextrin-Attached Cationic Ammonium Surfactants by a Supramolecular Approach
文献类型：期刊论文
| 作者 | Zhou, Chengcheng1; Wang, Hua1; Bai, Haotian2; Zhang, Pengbo2; Liu, Libing2; Wang, Shu2,3; Wang, Yilin1,3 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017-09-20 |
| 卷号 | 9期号:37页码:31657-31666 |
| 关键词 | Cyclodextrin-based Cationic Surfactant Aggregates Host-guest Interaction Antimicrobial Activity Cytotoxicity |
| 英文摘要 | Two beta-cyclodextrin-attached cationic ammonium surfactants bearing a dodecyl chain (APDB) and a hexadecyl chain (APCB) were synthesized to reduce the cytotoxicity of cationic surfactants to mammalian cells and endow the surfactants with host guest recognition sites, and three kinds of guest molecules were utilized to improve the antibacterial ability of APDB and APCB via host guest interaction by regulating the electrostatic or hydrophobic interaction of APDB or APCB with bacteria. The guest molecules include AD-NH3+ carrying one positive charge, DB with a benzene ring group and a dodecyl chain, and single chain cationic ammonium surfactant DTAB or CTAB. Either AD-NH3+ or DB increases the killing efficacy of APCB against S. aureus at 50 mu M from 59% to about 75%, while DTAB or CTAB improves the killing efficacy of APCB to more than 90%. In particular, only a very small amount CTAB can improve the antibacterial activity of APCB to a very high level, but keeps very low cytotoxicity. However, the mixtures of the guest molecules with APDB are devoid of any activity against S. aureus. This is mainly attributed to the fact that APCB and its mixtures with the guest molecules form 100-200 nm spherical aggregates, while the mixtures of APDB with the guest molecules cannot form aggregates at lower concentration. It is revealed that the three kinds of guest molecules trapped in the APCB spherical aggregates lead to diverse interaction modes of the APCB spherical aggregates with S. aureus, accounting for the different killing efficacy of the APCB/guest molecule mixtures. This supramolecular strategy provides an effective approach for the construction of highly efficient antibacterial agents with low cytotoxicity. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/41108]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Colloid & Interface Sci, BNLMS, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Key Lab Organ Solids, BNLMS, CAS Res Educ Ctr Excellence Mol Sci,Inst Chem, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Chengcheng,Wang, Hua,Bai, Haotian,et al. Tuning Antibacterial Activity of Cyclodextrin-Attached Cationic Ammonium Surfactants by a Supramolecular Approach[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(37):31657-31666. |
| APA | Zhou, Chengcheng.,Wang, Hua.,Bai, Haotian.,Zhang, Pengbo.,Liu, Libing.,...&Wang, Yilin.(2017).Tuning Antibacterial Activity of Cyclodextrin-Attached Cationic Ammonium Surfactants by a Supramolecular Approach.ACS APPLIED MATERIALS & INTERFACES,9(37),31657-31666. |
| MLA | Zhou, Chengcheng,et al."Tuning Antibacterial Activity of Cyclodextrin-Attached Cationic Ammonium Surfactants by a Supramolecular Approach".ACS APPLIED MATERIALS & INTERFACES 9.37(2017):31657-31666. |
入库方式： OAI收割
来源：化学研究所
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