Synthesis, G-quadruplex binding properties and cytotoxicity of naphthalimide-thiourea conjugates
文献类型：期刊论文
| 作者 | Ou, Zhize1; Xu, Moheng1; Gao, Yunyan1; Hu, Rui2; Li, Qingqing1; Cai, Wenjiao1; Wang, Ziji1; Qian, Yimeng1; Yang, Guoqiang2 |
| 刊名 | NEW JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2017-09-07 |
| 卷号 | 41期号:17页码:9397-9405 |
| 英文摘要 | Four novel naphthalimide-thiourea conjugates 3a-d have been prepared and characterized. The interactions of these compounds with duplex and telomeric G-quadruplex DNA have been investigated by UV-Vis spectroscopy, fluorescence spectroscopy, viscosity and cyclic voltammetric measurements. The studies reveal that 3a-d possess high affinity (>1.20 x 10(7) M-1) and reasonable selectivity for telomeric G-quadruplex DNA over duplex DNA. Viscosity and cyclic voltammetric experiments suggest that 3a-d bind to duplex DNA through a classical intercalation mode. Molecular docking studies indicate that 3a-d associate with telomeric G-quadruplexes through groove binding, and hydrogen bonding interactions exist between the thiourea moiety and the phosphates or the bases in the G-quadruplex. The emissive nature of compounds 3a-d makes it possible to study their localization in A549 cells by fluorescence microscopy. The representative compounds 3d and 3b are mainly localized in the nuclei after 4 h of incubation. All four compounds inhibit A549 cells selectively over normal HUVEC cells, with a higher antitumor activity than amonafide. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/41250]  |
| 专题 | 化学研究所_光化学实验室 |
| 作者单位 | 1.Northwestern Polytech Univ, Sch Sci, Dept Appl Chem, Key Lab Space Appl Phys & Chem,Minist Educ, Xian 710072, Peoples R China 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ou, Zhize,Xu, Moheng,Gao, Yunyan,et al. Synthesis, G-quadruplex binding properties and cytotoxicity of naphthalimide-thiourea conjugates[J]. NEW JOURNAL OF CHEMISTRY,2017,41(17):9397-9405. |
| APA | Ou, Zhize.,Xu, Moheng.,Gao, Yunyan.,Hu, Rui.,Li, Qingqing.,...&Yang, Guoqiang.(2017).Synthesis, G-quadruplex binding properties and cytotoxicity of naphthalimide-thiourea conjugates.NEW JOURNAL OF CHEMISTRY,41(17),9397-9405. |
| MLA | Ou, Zhize,et al."Synthesis, G-quadruplex binding properties and cytotoxicity of naphthalimide-thiourea conjugates".NEW JOURNAL OF CHEMISTRY 41.17(2017):9397-9405. |
入库方式： OAI收割
来源：化学研究所
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