Magnetic tweezers for the mechanical research of DNA at the single molecule level
文献类型：期刊论文
| 作者 | Xin, Qi1; Li, Peng2; He, Yuning1; Shi, Cuiping1; Qiao, Yiqun1; Bian, Xiaojun1; Su, Jing3; Qiao, Ruirui4; Zhou, Xinbo5; Zhong, Jian1,6 |
| 刊名 | ANALYTICAL METHODS
 |
| 出版日期 | 2017-10-21 |
| 卷号 | 9期号:39页码:5720-5730 |
| 英文摘要 | Biomechanical forces are involved in the physiological function of molecules. Single molecule magnetic tweezers have been developed and used to investigate the mechanical properties of individual biomolecules and their interactions. In this review, we will mainly review the application of magnetic tweezers for the mechanical research of DNA at the single molecule level. Firstly, we will briefly introduce the fundamentals and the categories of the instrumental setups. Secondly, we will summarize and discuss the application of magnetic tweezers for the analysis of the mechanical properties of DNA and the interactions between DNA and different substances such as DNA-modifying enzymes, DNA structural proteins, cations, drugs, and organic chemicals. Finally, the advantages and disadvantages of magnetic tweezers for DNA research are discussed. This work will provide an important guide to the scientists in the field of DNA mechanics. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/41277]  |
| 专题 | 化学研究所_胶体、界面与化学热力学实验室 |
| 作者单位 | 1.Shanghai Ocean Univ, Lab Qual & Safety Risk Assessment Aquat Prod Stor, Shanghai Engn Res Ctr Aquat Prod Proc & Preservat, Minist Agr,Coll Food Sci & Technol, Shanghai 201306, Peoples R China 2.Univ Coll Dublin, Sch Chem & Chem Biol, Dublin 4, Ireland 3.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 4.Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic, Australia 5.Beijing Inst Pharmacol & Toxicol, Lab Comp Aided Drug Design & Discovery, Beijing 100850, Peoples R China 6.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid & Interface & Chem Thermodyna, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xin, Qi,Li, Peng,He, Yuning,et al. Magnetic tweezers for the mechanical research of DNA at the single molecule level[J]. ANALYTICAL METHODS,2017,9(39):5720-5730. |
| APA | Xin, Qi.,Li, Peng.,He, Yuning.,Shi, Cuiping.,Qiao, Yiqun.,...&Zhong, Jian.(2017).Magnetic tweezers for the mechanical research of DNA at the single molecule level.ANALYTICAL METHODS,9(39),5720-5730. |
| MLA | Xin, Qi,et al."Magnetic tweezers for the mechanical research of DNA at the single molecule level".ANALYTICAL METHODS 9.39(2017):5720-5730. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。