In vitro evaluation of a novel pH neutral calcium phosphosilicate bioactive glass that does not require preconditioning prior to use
文献类型：期刊论文
| 作者 | Li, Ailing1; Lv, Yang2; Ren, Huihui1,3; Cui, Yang1,3; Wang, Chao1,3; Martin, Richard A.4,5; Qiu, Dong1,3 |
| 刊名 | INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 8期号:4页码:403-411 |
| 关键词 | Bioglass Ph Neutral Sol-gel |
| 英文摘要 | It is well known that bioactive glasses can cause a significant increase in pH due to the rapid release of calcium and/or sodium ions. Consequently, preconditioning of the glass is usually required prior to surgery to negate the effect of this sudden release of ions. However, preconditioning for several days is far from ideal and also preconditioning is not practical for novel organic/inorganic sol-gel hybrids currently being developed since the organic phase will start to hydrolyze and dissolve. This study describes a bioactive glass that dissolves without causing a significant change in pH from physiologically optimal values and requires no preconditioning prior to use. The bioactivity of the pH neutral glass, hydroxyapatite formation, and cellular responses, are measured and compared directly with results from archetypal 45S5 and S70C30 bioactive glasses. A hydroxyapatite layer was found to rapidly form (within 1day) on the surface of the pH neutral glass upon reacting with simulated body fluid. In addition, improved cell compatibility was observed compared with 45S5 and S70C30 glasses. Therefore, this pH neutral glass has significant potential for bone repair applications. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/41304]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Inst Chem, Beijing, Peoples R China 2.Peking Univ, Hosp 3, Orthoped Dept, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Aston Univ, Sch Engn & Appl Sci, Aston Inst Mat Res, Birmingham, W Midlands, England 5.Aston Univ, Aston Res Ctr Hlth Ageing, Birmingham, W Midlands, England |
| 推荐引用方式 GB/T 7714 | Li, Ailing,Lv, Yang,Ren, Huihui,et al. In vitro evaluation of a novel pH neutral calcium phosphosilicate bioactive glass that does not require preconditioning prior to use[J]. INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE,2017,8(4):403-411. |
| APA | Li, Ailing.,Lv, Yang.,Ren, Huihui.,Cui, Yang.,Wang, Chao.,...&Qiu, Dong.(2017).In vitro evaluation of a novel pH neutral calcium phosphosilicate bioactive glass that does not require preconditioning prior to use.INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE,8(4),403-411. |
| MLA | Li, Ailing,et al."In vitro evaluation of a novel pH neutral calcium phosphosilicate bioactive glass that does not require preconditioning prior to use".INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE 8.4(2017):403-411. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。