C-2-Symmetric Chiral Bisoxazolines as Hydrogen-Bond-Acceptor Catalysts in Enantioselective Aldol Reaction of beta-Carbonyl Acids with Trifluoroacetaldehyde Hemiacetals
文献类型：期刊论文
| 作者 | Yang, Zhen-Yan1,2; Zeng, Jun-Liang1,2; Ren, Nan1,2; Meng, Wei3; Nie, Jing1,2; Ma, Jun-An1,2 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2016-12-16 |
| 卷号 | 18期号:24页码:6364-6367 |
| 英文摘要 | A simple C-2-symmetric chiral bisoxazoline is demonstrated to use hydrogen bonding to catalyze an important family of aldol reactions of trifluoroacetaldehyde hemiacetals with various beta-carbonyl acids. This reaction is highly enantioselective, delivering chiral nonracemic trifluoromethylated alcohols with excellent optical purity and good isolated yields. This concept of relaying chiral information via a chiral hydrogen-bond acceptor should be applicable to a vast number of organo catalytic processes. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/37966]  |
| 专题 | 化学研究所_其它 |
| 作者单位 | 1.Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China 2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Zhen-Yan,Zeng, Jun-Liang,Ren, Nan,et al. C-2-Symmetric Chiral Bisoxazolines as Hydrogen-Bond-Acceptor Catalysts in Enantioselective Aldol Reaction of beta-Carbonyl Acids with Trifluoroacetaldehyde Hemiacetals[J]. ORGANIC LETTERS,2016,18(24):6364-6367. |
| APA | Yang, Zhen-Yan,Zeng, Jun-Liang,Ren, Nan,Meng, Wei,Nie, Jing,&Ma, Jun-An.(2016).C-2-Symmetric Chiral Bisoxazolines as Hydrogen-Bond-Acceptor Catalysts in Enantioselective Aldol Reaction of beta-Carbonyl Acids with Trifluoroacetaldehyde Hemiacetals.ORGANIC LETTERS,18(24),6364-6367. |
| MLA | Yang, Zhen-Yan,et al."C-2-Symmetric Chiral Bisoxazolines as Hydrogen-Bond-Acceptor Catalysts in Enantioselective Aldol Reaction of beta-Carbonyl Acids with Trifluoroacetaldehyde Hemiacetals".ORGANIC LETTERS 18.24(2016):6364-6367. |
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来源：化学研究所
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