A Voltage-Responsive Free-Blockage Controlled-Release System Based on Hydrophobicity Switching
文献类型：期刊论文
| 作者 | Jiao, Xiangyu1; Sun, Ruijuan1; Cheng, Yaya1; Li, Fengyu2; Du, Xin1; Wen, Yongqiang1; Song, Yanlin2; Zhang, Xueji1 |
| 刊名 | CHEMPHYSCHEM
 |
| 出版日期 | 2017-05-19 |
| 卷号 | 18期号:10页码:1317-1323 |
| 关键词 | Controlled Release Hydrophilic Effect Hydrophobic Effect Mesoporous Materials Nanotechnology |
| 英文摘要 | Controlled-release systems based on mesoporous silica nanomaterials (MSNs) have drawn great attention owing to their potential biomedical applications. Various switches have been designed to control the release of cargoes through the construction of physical blocking units on the surface of MSNs. However, such physical blockages are limited by poor sealing ability and low biocompatibility, and most of them lack closure ability. Herein, a voltage-responsive controlled-release system was constructed by functionalizing the nanopore of MSNs with ferrocene. The system realized free-blockage controlled release and achieved pulsatile release. The nanopores of the ferrocene-functionalized MSNs were hydrophobic enough to prevent invasion of the solution. Once a suitable voltage was applied, the nanopores became hydrophilic, which was followed by invasion of the solution and the release of the cargos. Moreover, pulsatile release was realized, which avoided unexpected release after the stimulus disappeared. Thus, we believe that our studies provide new insight into highly effective blockage for MSNs. Furthermore, the voltage-responsive release system is expected to find use in electrical stimulation combination therapy and bioelectricity-responsive release. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38557]  |
| 专题 | 化学研究所_绿色印刷实验室 |
| 作者单位 | 1.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Key Lab Green Printing,Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiao, Xiangyu,Sun, Ruijuan,Cheng, Yaya,et al. A Voltage-Responsive Free-Blockage Controlled-Release System Based on Hydrophobicity Switching[J]. CHEMPHYSCHEM,2017,18(10):1317-1323. |
| APA | Jiao, Xiangyu.,Sun, Ruijuan.,Cheng, Yaya.,Li, Fengyu.,Du, Xin.,...&Zhang, Xueji.(2017).A Voltage-Responsive Free-Blockage Controlled-Release System Based on Hydrophobicity Switching.CHEMPHYSCHEM,18(10),1317-1323. |
| MLA | Jiao, Xiangyu,et al."A Voltage-Responsive Free-Blockage Controlled-Release System Based on Hydrophobicity Switching".CHEMPHYSCHEM 18.10(2017):1317-1323. |
入库方式： OAI收割
来源：化学研究所
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