Engineered 3D Bioimplants Using Nucleus Pulposus Cells and Poly(L-lactide-co-glycode) Scaffolds for Intervertebral Disc Regeneration
文献类型：期刊论文
| 作者 | Zhang, Chao; Ruan, Dike; Zhang, Rongfeng; Xin, Hongkui; Wang, Shenguo; Yang, Fei |
| 刊名 | JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
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| 出版日期 | 2014-12-01 |
| 卷号 | 4期号:12页码:1040-1046 |
| 英文摘要 | Large area mapping of inorganic material in biological samples has suffered severely from prohibitively long acquisition times. With the advent of new detector technology we can now generate statistically relevant information for studying cell populations, inter-variability and bioinorganic chemistry in large specimen. We have been implementing ultrafast synchrotron-based XRF mapping afforded by the MAIA detector for large area mapping of biological material. For example, a 2.5 million pixel map can be acquired in 3 hours, compared to a typical synchrotron XRF set-up needing over 1 month of uninterrupted beamtime. Of particular focus to us is the fate of metals and nanoparticles in cells, 3D tissue models and animal tissues. The large area scanning has for the first time provided statistically significant information on sufficiently large numbers of cells to provide data on intercellular variability in uptake of nanoparticles. Techniques such as flow cytometry generally require analysis of thousands of cells for statistically meaningful comparison, due to the large degree of variability. Large area XRF now gives comparable information in a quantifiable manner. Furthermore, we can now image localised deposition of nanoparticles in tissues that would be highly improbable to 'find' by typical XRF imaging. In addition, the ultra fast nature also makes it viable to conduct 3D XRF tomography over large dimensions.This technology avails new opportunities in biomonitoring and understanding metal and nanoparticle fate ex-vivo. Following from this is extension to molecular imaging through specific anti-body targeted nanoparticles to label specific tissues and monitor cellular process or biological consequence. |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38595]  |
| 专题 | 化学研究所_其它 |
| 推荐引用方式 GB/T 7714 | Zhang, Chao,Ruan, Dike,Zhang, Rongfeng,et al. Engineered 3D Bioimplants Using Nucleus Pulposus Cells and Poly(L-lactide-co-glycode) Scaffolds for Intervertebral Disc Regeneration[J]. JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,2014,4(12):1040-1046. |
| APA | Zhang, Chao,Ruan, Dike,Zhang, Rongfeng,Xin, Hongkui,Wang, Shenguo,&Yang, Fei.(2014).Engineered 3D Bioimplants Using Nucleus Pulposus Cells and Poly(L-lactide-co-glycode) Scaffolds for Intervertebral Disc Regeneration.JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,4(12),1040-1046. |
| MLA | Zhang, Chao,et al."Engineered 3D Bioimplants Using Nucleus Pulposus Cells and Poly(L-lactide-co-glycode) Scaffolds for Intervertebral Disc Regeneration".JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 4.12(2014):1040-1046. |
入库方式： OAI收割
来源：化学研究所
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