A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals
文献类型：期刊论文
| 作者 | Zhen, Mingming; Shu, Chunying; Li, Jie; Zhang, Guoqiang; Wang, Taishan; Luo, Yi; Zou, Toujun; Deng, Ruijun; Fang, Fang; Lei, Hao |
| 刊名 | SCIENCE CHINA-MATERIALS
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 58期号:10页码:799-810 |
| 英文摘要 | It has long been a dream to achieve tumor targeting therapy that can efficiently reduce the toxicity and severe side effects of conventional antitumor chemotherapeutic agents. Taking advantage of the abnormalities of tumor vasculature, we demonstrate here a new powerful tumor vascular-targeting therapeutic technique for solid cancers that applies advanced nanotechnology to cut off the nutrient supply of tumor cells by physically destroying the abnormal tumor blood vessels. Water soluble magnetic Gd@C-82 nanocrystals of the chosen sizes are deliberately designed with abilities to penetrate into the leaky tumor blood vessels. By triggering the radiofrequency induced phase transition of gadofullerene nanocrystals while extravasating the tumor blood vessel, the explosive structural change of nanoparticles generates a devastating impact on abnormal tumor blood vessels, resulting in a rapid and extensive ischemia necrosis and shrinkage of the tumors. This unprecedented target-specific physiotherapy is found to work perfectly for advanced and refractory solid tumors. |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38661]  |
| 专题 | 化学研究所_其它 |
| 推荐引用方式 GB/T 7714 | Zhen, Mingming,Shu, Chunying,Li, Jie,et al. A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals[J]. SCIENCE CHINA-MATERIALS,2015,58(10):799-810. |
| APA | Zhen, Mingming.,Shu, Chunying.,Li, Jie.,Zhang, Guoqiang.,Wang, Taishan.,...&Bai, Chunli.(2015).A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals.SCIENCE CHINA-MATERIALS,58(10),799-810. |
| MLA | Zhen, Mingming,et al."A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals".SCIENCE CHINA-MATERIALS 58.10(2015):799-810. |
入库方式： OAI收割
来源：化学研究所
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