High T-1- and T-2-Contrast Ability of Ultra-Fine PEGylated Iron Oxide Nanoparticles in Ultra-Low Field MRI Measured By a High-T-c DC-SQUID
文献类型：期刊论文
| 作者 | Jin Yirong; Jia Qiaojuan; Deng Hui; Wang Ning; Jiang Fengying; Tian Ye; Gao Mingyuan; Zheng Dongning |
| 刊名 | IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 25期号:3 |
| 英文摘要 | The effect of ultra-fine superparamagnetic PEGylated iron oxide nanoparticles (SPIONs) on the H-1 nuclei spin relaxation time T-1 and T-2 were systematically investigated for the performance as T-1 or T-2 contrast agents in ultra-low field (ULF) nuclear magnetic resonance and resonance imaging (NMR&MRI). A high-T-c dc-SQUID sensor was used to detect the resonance signal from water samples containing SPIONs of different sizes and concentrations. The relaxation rates (T (1,2) (-1)) was shown to depend linearly on the iron concentration (C, in mMol of Fe). The relaxivities (defined as d(T-1,2(-1))/dC) r(1) and r(2) were fitted and compared with high field (3 T) NMR results. An impressive improvement of more than an order in r(1) was found for all SPIONs of different sizes, which leads to a much lowered relaxivity ratio r(2)/r(1). For all SPIONs measured, r(2)/r(1) was around 1, which implies that SPIONs are high performance T1 contrast agent in ULF NMR& MRI. The highest r(1) and r(2) values were found in the sample containing 16.7 nm nanoparticles, both of them being around 200 mMol(-1) s(-1). Furthermore, we also demonstrated T-1-weighted contrast imaging using 16.7 nm nanoparticles. Clear intensity gradient were shown in the images, indicating a good contrast enhancement capability. |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38678]  |
| 专题 | 化学研究所_其它 |
| 推荐引用方式 GB/T 7714 | Jin Yirong,Jia Qiaojuan,Deng Hui,et al. High T-1- and T-2-Contrast Ability of Ultra-Fine PEGylated Iron Oxide Nanoparticles in Ultra-Low Field MRI Measured By a High-T-c DC-SQUID[J]. IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY,2015,25(3). |
| APA | Jin Yirong.,Jia Qiaojuan.,Deng Hui.,Wang Ning.,Jiang Fengying.,...&Zheng Dongning.(2015).High T-1- and T-2-Contrast Ability of Ultra-Fine PEGylated Iron Oxide Nanoparticles in Ultra-Low Field MRI Measured By a High-T-c DC-SQUID.IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY,25(3). |
| MLA | Jin Yirong,et al."High T-1- and T-2-Contrast Ability of Ultra-Fine PEGylated Iron Oxide Nanoparticles in Ultra-Low Field MRI Measured By a High-T-c DC-SQUID".IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY 25.3(2015). |
入库方式： OAI收割
来源：化学研究所
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