Ultra-tough injectable cytocompatible hydrogel for 3D cell culture and cartilage repair
文献类型：期刊论文
| 作者 | Zhao, Yanran; Li, Mengnan; Liu, Bingchuan; Xiang, Junfeng; Cui, Zhiyong; Qu, Xiaozhong; Qiu, Dong; Tian, Yun; Yang, Zhenzhong |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | MAR 7 2018 |
| 卷号 | 6期号:9页码:1351-1358 |
| 英文摘要 | In this work, we developed a very facile strategy, i.e. dual dynamic crosslinking, to prepare a high performance injectable hydrogel. Poly(vinyl alcohol) (PVA) was crosslinked by 4-carboxyphenylboronic acid (CPBA) through the generation of borate bonding and ionic interaction to bridge the polymer chains in the presence of calcium ions. The dynamic gathering of CPBA could induce a self-reinforcing effect inside the hydrogel matrix, leading to high tensile and compressive moduli of the hydrogel over 1.0 MPa including the highest compressive modulus up to 5.6 MPa. Meanwhile, the mechanical properties of the hydrogel can be broadly and accurately tuned. And owing to the flexible PVA network, the hydrogel is ultra-tough, showing maximum tensile strain, tensile and compressive fracture energies up to 1600%, 600 kJ m(-2) and 25 kJ m(-2), respectively. Besides, the dynamic bonding overcomes the barriers to forming an injected strong hydrogel, e.g. to obtain a modulus and a fracture energy exceeding 1.0 MPa and 40 kJ m(-2), by using a commercial dual-syringe kit under physiological conditions. Such a mild gelation procedure benefits the administration, 3D encapsulation and proliferation of cells of the hydrogels. The application of the PVA hydrogel was demonstrated by effective cartilage repair. |
| WOS记录号 | WOS:000426706900007 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38721]  |
| 专题 | 化学研究所_其它 |
| 推荐引用方式 GB/T 7714 | Zhao, Yanran,Li, Mengnan,Liu, Bingchuan,et al. Ultra-tough injectable cytocompatible hydrogel for 3D cell culture and cartilage repair[J]. JOURNAL OF MATERIALS CHEMISTRY B,MAR ,6(9):1351-1358. |
| APA | Zhao, Yanran.,Li, Mengnan.,Liu, Bingchuan.,Xiang, Junfeng.,Cui, Zhiyong.,...&Yang, Zhenzhong.(MAR ).Ultra-tough injectable cytocompatible hydrogel for 3D cell culture and cartilage repair.JOURNAL OF MATERIALS CHEMISTRY B,6(9),1351-1358. |
| MLA | Zhao, Yanran,et al."Ultra-tough injectable cytocompatible hydrogel for 3D cell culture and cartilage repair".JOURNAL OF MATERIALS CHEMISTRY B 6.9(MAR ):1351-1358. |
入库方式： OAI收割
来源：化学研究所
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