Photothermal-Responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells
文献类型：期刊论文
| 作者 | Wang, Yunxia; Li, Shengliang; Zhang, Pengbo; Bai, Haotian; Feng, Liheng; Lv, Fengting; Liu, Libing; Wang, Shu |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | FEB 22 2018 |
| 卷号 | 30期号:8页码:- |
| 英文摘要 | Remote control and noninvasive manipulation of cellular bioprocess has received intensive attention as a powerful technology to control cell functions. Here, a strategy is developed to remotely control intracellular gene expression with high spatial and temporal resolutions by using photothermal-responsive conjugated polymer nanoparticles (CPNs) as the transducer under near-infrared light irradiation. After being modified with positive charged peptide, the CPNs with superior photothermal conversion capacity could effectively coat on the surface of living cells and generate localized heat to trigger target gene expression. The heat-inducible heat shock protein-70 promoter starts transcription of downstream EGFP gene in response to heat shock, thus producing green fluorescent protein in the living cells. The combination of heat-inducible gene promoter and photothermal-responsive CPNs provides a method for the development of thermogenetics. |
| WOS记录号 | WOS:000425449300024 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38756]  |
| 专题 | 化学研究所_其它 |
| 推荐引用方式 GB/T 7714 | Wang, Yunxia,Li, Shengliang,Zhang, Pengbo,et al. Photothermal-Responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells[J]. ADVANCED MATERIALS,FEB ,30(8):-. |
| APA | Wang, Yunxia.,Li, Shengliang.,Zhang, Pengbo.,Bai, Haotian.,Feng, Liheng.,...&Wang, Shu.(FEB ).Photothermal-Responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells.ADVANCED MATERIALS,30(8),-. |
| MLA | Wang, Yunxia,et al."Photothermal-Responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells".ADVANCED MATERIALS 30.8(FEB ):-. |
入库方式： OAI收割
来源：化学研究所
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