Metal-free tandem cyclization/hydrosilylation to construct tetrahydroquinoxalines
文献类型：期刊论文
| 作者 | Pan, Yixiao; Chen, Changjun; Xu, Xin; Zhao, Haoqiang; Han, Jiahong; Li, Huanrong; Xu, Lijin; Fan, Qinghua; Xiao, Jianliang |
| 刊名 | GREEN CHEMISTRY
 |
| 出版日期 | JAN 21 2018 |
| 卷号 | 20期号:2页码:403-411 |
| 英文摘要 | A one-pot tandem procedure involving cyclization and sequential hydrosilylation of imines and amides under the catalysis of B(C6F5)(3) has been developed for the step-economical construction of 1,2,3,4-tetrahydroquinoxalines directly from readily available 1,2-diaminobenzenes, alpha-ketoesters and low-cost, safe polymethylhydrosiloxane (PMHS). This metal-free approach provides various products in good to excellent yields, and displays a wide range of substrate scope and a high degree of functional group tolerance even to reduction-sensitive moieties. The choice of hydrosilanes is critical to the catalysis, and PMHS has proved to be optimal. Decreasing the amount of PMHS could enable the reaction to stop at the 3,4-dihydroquinoxalin-2(1H)-one stage. The procedure is convenient and scalable, and neither a dried solvent nor an inert atmosphere is required. Moreover, the enantioselective construction of these products was explored, and promising results were achieved. |
| WOS记录号 | WOS:000423337500010 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38834]  |
| 专题 | 化学研究所_其它 |
| 推荐引用方式 GB/T 7714 | Pan, Yixiao,Chen, Changjun,Xu, Xin,et al. Metal-free tandem cyclization/hydrosilylation to construct tetrahydroquinoxalines[J]. GREEN CHEMISTRY,JAN ,20(2):403-411. |
| APA | Pan, Yixiao.,Chen, Changjun.,Xu, Xin.,Zhao, Haoqiang.,Han, Jiahong.,...&Xiao, Jianliang.(JAN ).Metal-free tandem cyclization/hydrosilylation to construct tetrahydroquinoxalines.GREEN CHEMISTRY,20(2),403-411. |
| MLA | Pan, Yixiao,et al."Metal-free tandem cyclization/hydrosilylation to construct tetrahydroquinoxalines".GREEN CHEMISTRY 20.2(JAN ):403-411. |
入库方式： OAI收割
来源：化学研究所
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