N-Phenyl-2-naphthylamine as a Novel MALDI Matrix for Analysis and in Situ Imaging of Small Molecules
文献类型：期刊论文
| 作者 | Liu, Huihui; Zhou, Yueming; Wang, Jiyun; Xiong, Caiqiao; Xue, Jinjuan; Zhan, Lingpeng; Nie, Zongxiu |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | JAN 2 2018 |
| 卷号 | 90期号:1页码:729-736 |
| 英文摘要 | Due to its strong ultraviolet absorption, low background interference in the small molecular range, and salt tolerance capacity, N-phenyl-2-naphthylamine (PNA) was developed as a novel matrix in the present study for analysis and imaging of small molecules by matrix-assisted laser desorption/ionization mass spectrometry time of-fight (MALDI-TOF MS). The newly developed matrix displayed good performance in analysis of a wide range of small-molecule metabolites including free fatty acids, amino adds, peptides, antioxidants, and phospholipids. In addition, PNA-assisted LDI MS imaging of small molecules in brain tissue of rats subjected to middle cerebral artery occlusion (MCAO) revealed unique distributions and changes of 89 small-molecule metabolites including amino acids, antioxidants, free fatty acids, phospholipids, and sphingolipids in brain tissue 24 h postsurgery. Fifty-nine of the altered metabolites were identified, and all the changed metabolites were subject to relative quantitation and statistical analysis. The newly developed matrix has great potential application in the field of biomedical research. |
| WOS记录号 | WOS:000419419200047 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38863]  |
| 专题 | 化学研究所_其它 |
| 推荐引用方式 GB/T 7714 | Liu, Huihui,Zhou, Yueming,Wang, Jiyun,et al. N-Phenyl-2-naphthylamine as a Novel MALDI Matrix for Analysis and in Situ Imaging of Small Molecules[J]. ANALYTICAL CHEMISTRY,JAN ,90(1):729-736. |
| APA | Liu, Huihui.,Zhou, Yueming.,Wang, Jiyun.,Xiong, Caiqiao.,Xue, Jinjuan.,...&Nie, Zongxiu.(JAN ).N-Phenyl-2-naphthylamine as a Novel MALDI Matrix for Analysis and in Situ Imaging of Small Molecules.ANALYTICAL CHEMISTRY,90(1),729-736. |
| MLA | Liu, Huihui,et al."N-Phenyl-2-naphthylamine as a Novel MALDI Matrix for Analysis and in Situ Imaging of Small Molecules".ANALYTICAL CHEMISTRY 90.1(JAN ):729-736. |
入库方式： OAI收割
来源：化学研究所
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