Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability
文献类型：期刊论文
| 作者 | Chen, Hui; Li, Meng; Liu, Zhang; Hu, Rong; Li, Shengliang; Guo, Yuan; Lv, Fengting; Liu, Libing; Wang, Yilin; Yi, Yuanping |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2018 |
| 卷号 | 61期号:1页码:113-117 |
| 英文摘要 | Increasing multidrug-resistant (MDR) superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-(7,7'-bifluoren-benzo[c][1,2,5]thiadiazole) (OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration (MIC) below 3.0 mu M. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent. |
| WOS记录号 | WOS:000419997000013 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/38879]  |
| 专题 | 化学研究所_其它 |
| 推荐引用方式 GB/T 7714 | Chen, Hui,Li, Meng,Liu, Zhang,et al. Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability[J]. SCIENCE CHINA-CHEMISTRY,2018,61(1):113-117. |
| APA | Chen, Hui.,Li, Meng.,Liu, Zhang.,Hu, Rong.,Li, Shengliang.,...&Wang, Shu.(2018).Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability.SCIENCE CHINA-CHEMISTRY,61(1),113-117. |
| MLA | Chen, Hui,et al."Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability".SCIENCE CHINA-CHEMISTRY 61.1(2018):113-117. |
入库方式： OAI收割
来源：化学研究所
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