中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Enhanced Synergism of Thermo-chemotherapy For Liver Cancer with Magnetothermally Responsive Nanocarriers

文献类型:期刊论文

作者Li, Minghua; Bu, Wenbo; Ren, Jie; Li, Jianbo; Deng, Li; Gao, Mingyuan; Gao, Xiaolong; Wang, Peijun
刊名THERANOSTICS
出版日期2018
卷号8期号:3页码:693-709
英文摘要A combination of magnetic hyperthermia and magnetothermally-facilitated drug release system was developed as a promising strategy for liver cancer therapy. The thermosensitive copolymer, 6sPCL-b-P(MEO(2)MA-co-OEGMA) shows a good temperature-controlled drug release response. Mn-Zn ferrite magnetic nanoparticles (MZF-MNPs) exhibit a strong magnetic thermal effect with an alternating magnetic field (AMF). Owing to its high magnetic sensitivity, the magnetothermally-responsive nanocarrier/doxorubicin (MTRN/DOX) can be concentrated in the tumor site efficiently through magnetic targeting. Given this information, we synthesized MTRN/DOX which was composed of MZF-MNPs, thermosensitive copolymer drug carriers, and the chemotherapeutic drug-DOX, to study its anticancer effects both in vitro and in vivo.METHODS: MTRN/DOX was designed and prepared. Firstly, we investigated the accumulation effects of MTRN/DOX by Prussian blue staining, transmission electron microscopy (TEM), laser scanning confocal microscopy (LSCM) and conducted 7.0 T MRI. Following this, the magnetothermal effects of MTRN/DOX were studied using an infrared thermal camera. DOX uptake, distribution, and retention in tumor cells and the distribution of MTRN/DOX in vivo were then analyzed via LSCM, flow cytometry and live fluorescence imaging. Lastly, its anticancer effects were evaluated by MTT, AM/PI staining, Annexin-VFITC/PI staining and comparison of relative tumor volume.RESULTS: We found that MTRN/DOX can be efficiently concentrated in the tumor site through magnetic targeting, increasing the uptake of DOX by tumor cells, and prolonging the retention time of the drug within the tumors. MTRN/DOX showed good magnetothermal effects both in vitro and in vivo. Based on the above results, MTRN/DOX had significant anticancer effects.CONCLUSIONS: MTRN/DOX causes temporal-spatial synchronism of thermo-chemotherapy and together with chemotherapeutic drugs, produces a synergistic effect, which enhances the sensitivity of tumor cells to DOX and reduces their side effects.
WOS记录号WOS:000417132600008
源URL[http://ir.iccas.ac.cn/handle/121111/38886]  
专题化学研究所_其它
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Li, Minghua,Bu, Wenbo,Ren, Jie,et al. Enhanced Synergism of Thermo-chemotherapy For Liver Cancer with Magnetothermally Responsive Nanocarriers[J]. THERANOSTICS,2018,8(3):693-709.
APA Li, Minghua.,Bu, Wenbo.,Ren, Jie.,Li, Jianbo.,Deng, Li.,...&Wang, Peijun.(2018).Enhanced Synergism of Thermo-chemotherapy For Liver Cancer with Magnetothermally Responsive Nanocarriers.THERANOSTICS,8(3),693-709.
MLA Li, Minghua,et al."Enhanced Synergism of Thermo-chemotherapy For Liver Cancer with Magnetothermally Responsive Nanocarriers".THERANOSTICS 8.3(2018):693-709.

入库方式: OAI收割

来源:化学研究所

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