Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity
文献类型：期刊论文
| 作者 | Sun, Shuhong1; Wang, Ran1; Song, Jianwen1; Guan, Ming2; Li, Na2; Zhang, Xiaotian1; Zhao, Zhenwen2; Zhang, Junjie1 |
| 刊名 | JOURNAL OF LIPID RESEARCH
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 58期号:11页码:2102-2113 |
| 关键词 | Glycoprotein 130 Autotaxin Adipocyte Insulin Sensitivity Obesity |
| 英文摘要 | Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels. Upregulation of ATX expression in obese patients and mice is closely related with insulin resistance and impaired glucose tolerance. However, the mechanism of ATX expression in adipocytes remains largely unknown. In this study, we found that glycoprotein 130 (gp130)-mediated Janus kinase (JAK)-signal transducer and activator of transcription 3 (STAT3) activation was required for abundant ATX expression in adipocytes. Through gp130, the interleukin 6 (IL-6) family cytokines, such as IL-6, leukemia inhibitory factor, cardiotrophin-1, and ciliary neurotrophic factor, upregulated ATX expression in adipocytes. ATX contributes to the induction of insulin resistance and lipolysis in IL-6-stimulated adipocytes. Oral administration of gp130 inhibitor SC144 suppressed ATX expression in adipose tissue, decreased plasma ATX, LPA, and FFA levels, and significantly improved insulin sensitivity and glucose tolerance in high-fat diet-fed obese mice. In summary, our results indicate that the activation of gp130JAK- STAT3 pathway by IL-6 family cytokines has an important role in regulating ATX expression in adipocytes and that gp130 is a promising target in the management of obesity-associated glucose metabolic diseases. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/39170]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Beijing Normal Univ, Inst Cell Biol, Key Lab Cell Proliferat & Regulat Biol, Minist Educ,Coll Life Sci, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Shuhong,Wang, Ran,Song, Jianwen,et al. Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity[J]. JOURNAL OF LIPID RESEARCH,2017,58(11):2102-2113. |
| APA | Sun, Shuhong.,Wang, Ran.,Song, Jianwen.,Guan, Ming.,Li, Na.,...&Zhang, Junjie.(2017).Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity.JOURNAL OF LIPID RESEARCH,58(11),2102-2113. |
| MLA | Sun, Shuhong,et al."Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity".JOURNAL OF LIPID RESEARCH 58.11(2017):2102-2113. |
入库方式： OAI收割
来源：化学研究所
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