Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo
文献类型：期刊论文
| 作者 | Wei, Yongbiao1,6; Hu, Xiaoxiao3,4; Shen, Luyao1,2; Jin, Bing1; Liu, Xiangjun1,2; Tan, Weihong3,4,5; Shangguan, Dihua1,2 |
| 刊名 | EBIOMEDICINE
 |
| 出版日期 | 2017-09-01 |
| 卷号 | 23页码:25-33 |
| 关键词 | Photodynamic Therapy Near Infrared Photosensitizers Squaraines Cellular Uptake |
| 英文摘要 | The lack of ideal photosensitizers limits the clinical application of photodynamic therapy (PDT). Here we report the PDT efficiency of dicyanomethylene substituted benzothiazole squaraine derivatives. This class of squaraine derivatives possess strong absorption and long excitation and emission wavelengths (ex/em, 685/720 nm). They show negligible dark toxicity, but can generate singlet oxygen under irradiation resulting in the apoptosis and necrosis of cells (phototoxicity). Changing the side chains of these compounds greatly influences their albumin-binding rate, cellular uptake and their phototoxicity. One of the squaraine derivatives with two methyl butyrate side chains shows high PDT efficiency in a mouse subcutaneous xenograft model under the irradiation of a 690 nm laser. These results show the great potential of dicyanomethylene substituted benzothiazole squaraines to be the leading compound of near-infrared photosensitizers in PDT. (C) 2017 Published by Elsevier B.V. |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/41065]  |
| 专题 | 化学研究所_活体分析化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci,CAS Res Educ Ctr Excelle, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Hunan Univ, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemometr, Coll Biol, Changsha 410082, Hunan, Peoples R China 4.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China 5.Univ Florida, McKnight Brain Inst, Ctr Res Bio Nano Interface, Dept Chem,Hlth Canc Ctr,UF Genet Inst, Gainesville, FL 32611 USA 6.Guangxi Med Univ, Sch Pharmaceut Sci, Dept Pharmaceut Chem, 22 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Yongbiao,Hu, Xiaoxiao,Shen, Luyao,et al. Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo[J]. EBIOMEDICINE,2017,23:25-33. |
| APA | Wei, Yongbiao.,Hu, Xiaoxiao.,Shen, Luyao.,Jin, Bing.,Liu, Xiangjun.,...&Shangguan, Dihua.(2017).Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo.EBIOMEDICINE,23,25-33. |
| MLA | Wei, Yongbiao,et al."Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo".EBIOMEDICINE 23(2017):25-33. |
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来源：化学研究所
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