Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water
文献类型：期刊论文
| 作者 | Su, T; Li, MD; Ma, J; Phillips, DL |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2017 |
| 卷号 | 121期号:17页码:4512-4520 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/acs.jpcb.6b11267 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The mechanism of the defluorination reaction(s) of lomefloxacin (LF) upon light illumination was investigated by using ultrafast laser flash photolysis combined with transient resonance Raman spectroscopy in near neutral water solution. The zwitterionic configuration of LF was determined to be the main species present in the near neutral water solution and was the species that was photoexcited to initiate the photochemical reaction. Femtosecond transient absorption revealed that the first excited singlet state (S-1) of LF did not appreciably undergo intersystem crossing (ISC), and instead partially decayed to the ground state via fluorescence emission, and there was partial cleavage of the carbon fluorine bond at position 8 to produce a singlet LF aryl cation intermediate. The transient resonance Raman results provided a direct observation and vibrational spectral characterization of the singlet LF aryl cation species. Subsequently, the transformation from the singlet LF aryl cation to a triplet carbene via an ISC process was seen in nanosecond transient absorption spectra. Finally, the triplet carbene experienced a cyclization reaction with the N-ethyl chain to form a tricyclic product. |
| 语种 | 英语 |
| WOS记录号 | WOS:000400881300020 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/27487]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Su, T,Li, MD,Ma, J,et al. Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2017,121(17):4512-4520. |
| APA | Su, T,Li, MD,Ma, J,&Phillips, DL.(2017).Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water.JOURNAL OF PHYSICAL CHEMISTRY B,121(17),4512-4520. |
| MLA | Su, T,et al."Time-Resolved Spectroscopic Study of the Defluorination and Cyclization Reactions of Lomefloxacin in Water".JOURNAL OF PHYSICAL CHEMISTRY B 121.17(2017):4512-4520. |
入库方式： OAI收割
来源：上海应用物理研究所
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