Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation
文献类型：期刊论文
| 作者 | Li, J; Green, AA; Yan, H; Fan, CH |
| 刊名 | NATURE CHEMISTRY
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:11页码:1056-1067 |
| 关键词 | Tetrahedral Dna Nanostructure Strand Displacement Cascades Hybridization Chain-reaction Green Fluorescent Protein Synthetic Biology Gene-expression Drug-delivery Logic Gates Mammalian-cells Living Cells |
| ISSN号 | 1755-4330 |
| DOI | 10.1038/nchem.2852 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Nucleic acids have attracted widespread attention due to the simplicity with which they can be designed to form discrete structures and programmed to perform specific functions at the nanoscale. The advantages of DNA/RNA nanotechnology offer numerous opportunities for in-cell and in-vivo applications, and the technology holds great promise to advance the growing field of synthetic biology. Many elegant examples have revealed the potential in integrating nucleic acid nanostructures in cells and in vivo where they can perform important physiological functions. In this Review, we summarize the current abilities of DNA/RNA nanotechnology to realize applications in live cells and then discuss the key problems that must be solved to fully exploit the useful properties of nanostructures. Finally, we provide viewpoints on how to integrate the tools provided by DNA/RNA nanotechnology and related new technologies to construct nucleic acid nanostructure-based molecular circuitry for synthetic biology. |
| WOS关键词 | TETRAHEDRAL DNA NANOSTRUCTURE ; STRAND DISPLACEMENT CASCADES ; HYBRIDIZATION CHAIN-REACTION ; GREEN FLUORESCENT PROTEIN ; SYNTHETIC BIOLOGY ; GENE-EXPRESSION ; DRUG-DELIVERY ; LOGIC GATES ; MAMMALIAN-CELLS ; LIVING CELLS |
| 语种 | 英语 |
| WOS记录号 | WOS:000413569500006 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28641]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Li, J,Green, AA,Yan, H,et al. Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation[J]. NATURE CHEMISTRY,2017,9(11):1056-1067. |
| APA | Li, J,Green, AA,Yan, H,&Fan, CH.(2017).Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation.NATURE CHEMISTRY,9(11),1056-1067. |
| MLA | Li, J,et al."Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation".NATURE CHEMISTRY 9.11(2017):1056-1067. |
入库方式： OAI收割
来源：上海应用物理研究所
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