Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase
文献类型：期刊论文
| 作者 | Tian, J; Yan, QL; Zhu, Y; Zhang, JC; Li, J; Shi, B; Xu, G; Fan, CH; Zhao, CC |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2017 |
| 卷号 | 35期号:11页码:1711-1716 |
| 关键词 | Living Cells Selective Detection Fluoride-ion Transferase Homocysteine Glutathione Expression Cysteine Design Sensor |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.201700248 |
| 文献子类 | 期刊论文 |
| 英文摘要 | A fluorescent turn-on probe for specifically targeting gamma-glutamyltranspeptidase (GGT) was designed and synthesized by integrating boron-dipyrromethene (BODIPY) as a chromophore and glutathione (GSH) as the GGT substrate. GGT-catalyzed the cleavage of the gamma-glutamyl bond and generated the aromatic hydrocarbon transfer between the sulfur and the nitrogen atom in BODIPY, leading to distinct optical changes. Such specific responsiveness provides an easily distinguishable fluorescence signal to visualize the GGT activity in living cells and differentiate GGT-positive cancer cells from GGT-negative cells. |
| WOS关键词 | LIVING CELLS ; SELECTIVE DETECTION ; FLUORIDE-ION ; TRANSFERASE ; HOMOCYSTEINE ; GLUTATHIONE ; EXPRESSION ; CYSTEINE ; DESIGN ; SENSOR |
| 语种 | 英语 |
| WOS记录号 | WOS:000417173600010 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28644]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Tian, J,Yan, QL,Zhu, Y,et al. Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase[J]. CHINESE JOURNAL OF CHEMISTRY,2017,35(11):1711-1716. |
| APA | Tian, J.,Yan, QL.,Zhu, Y.,Zhang, JC.,Li, J.,...&Zhao, CC.(2017).Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase.CHINESE JOURNAL OF CHEMISTRY,35(11),1711-1716. |
| MLA | Tian, J,et al."Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related gamma-Glutamyltranspeptidase".CHINESE JOURNAL OF CHEMISTRY 35.11(2017):1711-1716. |
入库方式： OAI收割
来源：上海应用物理研究所
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