Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy
文献类型：期刊论文
| 作者 | Chen, WQ; Peng, Y; Jiang, XK; Zhao, JY; Zhao, HW; Zhu, YM |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:-页码:- |
| 关键词 | Magnetic-resonance-spectroscopy Density-functional Theory Gliomas (r)-2-hydroxyglutarate Radiation Cancer Idh1 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-017-11527-z |
| 文献子类 | 期刊论文 |
| 英文摘要 | 2-Hydroxyglutaric acid disodium salt (2HG) is a unique biomarker existing in glioma, which can be used for recognizing cancer development stage and identifying the boundary between the ordinary tissue and cancer tissue. However, the most efficient detection method for 2HG now is Magnetic Resonance Spectroscopy (MRS), whose testing time is at least twenty minutes and the variability of 2HG (continuous synthesis and decomposition) determines it cannot be used as the real-time image in medical surgery. In this paper, by using the Terahertz Time-domain Spectroscopy (THz-TDS) System, we investigate the vibration spectra of 2HG isomers and further distinguish their physical properties by using Density Functional Theory. The differences between isomers are mainly attributed to the proton transfer inside the carbon chain. These results indicate that terahertz technology can identify the isomers of 2HG accurate and fast, which has important significance for the further investigation of glioma and clinical surgery. |
| WOS关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY ; DENSITY-FUNCTIONAL THEORY ; GLIOMAS ; (R)-2-HYDROXYGLUTARATE ; RADIATION ; CANCER ; IDH1 |
| 语种 | 英语 |
| WOS记录号 | WOS:000411434900032 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28714]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Chen, WQ,Peng, Y,Jiang, XK,et al. Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy[J]. SCIENTIFIC REPORTS,2017,7(-):-. |
| APA | Chen, WQ,Peng, Y,Jiang, XK,Zhao, JY,Zhao, HW,&Zhu, YM.(2017).Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy.SCIENTIFIC REPORTS,7(-),-. |
| MLA | Chen, WQ,et al."Isomers Identification of 2-hydroxyglutarate acid disodium salt (2HG) by Terahertz Time-domain Spectroscopy".SCIENTIFIC REPORTS 7.-(2017):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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