Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage
文献类型：期刊论文
| 作者 | Zhu, B; Zhao, Y; Dai, JB; Wang, JB; Xing, S; Guo, LJ; Chen, N; Qu, XM; Li, L; Shen, JW |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:22页码:18434-18439 |
| 关键词 | Delivery Stability Origami Nanoparticles Complexes |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b04784 |
| 文献子类 | 期刊论文 |
| 英文摘要 | DNA rianostiuctures have: attracted wide interest-in biomedical applications, especially as nanocarriers for drug delivery. Therefore, it is.important to ensure:the structural integrity of DNA nanostructures under ambient temperature storage. In this study, we examined lyophilization-based preservation of DNA nanostructures by investigating the structural integrity of different DNA nanostructures reconstituted from lyophilization. We demonstrated that lyophilization Under appropriate ionic strength is amenable to the storage of DNA. nanostructures Compared with that stored in liquid solutiOn, DNA nanostructure carriers reconstituted from lyophilization showed significantly better structural integrity after an accelerated aging test equivalent to 100-day room-temperature storage. |
| WOS关键词 | DELIVERY ; STABILITY ; ORIGAMI ; NANOPARTICLES ; COMPLEXES |
| 语种 | 英语 |
| WOS记录号 | WOS:000403136400007 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28780]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhu, B,Zhao, Y,Dai, JB,et al. Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(22):18434-18439. |
| APA | Zhu, B.,Zhao, Y.,Dai, JB.,Wang, JB.,Xing, S.,...&Wang, LH.(2017).Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage.ACS APPLIED MATERIALS & INTERFACES,9(22),18434-18439. |
| MLA | Zhu, B,et al."Preservation of DNA Nanostructure Carriers: Effects of Freeze - Thawing and Ionic Strength during Lyophilization and Storage".ACS APPLIED MATERIALS & INTERFACES 9.22(2017):18434-18439. |
入库方式： OAI收割
来源：上海应用物理研究所
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