Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots
文献类型：期刊论文
| 作者 | Han, YP; Li, XM; Chen, HB; Hu, XJ; Luo, Y; Wang, T; Wang, ZJ; Li, Q; Fan, CH; Shi, JY |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:25页码:21200-21208 |
| 关键词 | Quantum Dots Cellular Uptake Drug-delivery Living Cells Live Cells Nanoparticles Cytotoxicity Fluorescence Transducer Insights |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b05662 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Semiconducting polymer dots (Pdots) have shown great promise in biomedical applications, including biosensing, drug delivery, and live imaging of cells and biomolecules. Insight into the mechanism and regulation of cellular uptake and intracellular metabolism. of Pdots is important for the development of superior Pdots-based theranostic nanoconjugates. Herein, we performed real-time imaging of endocytosis and intracellular trafficking of a type of fluorescent Pdots that showed excellent biocompatibility in various types of cells. The endocytic routes and kinetics of Pdots were differently regulated in distinct cell types. Following endocytosis, Pdots were transported in vesicles along micro tubule and destined for lysosomes. Furthermore, our results revealed exosome-mediated extracellular release of Pdots and have tracked the dynamic process at the single particle level. These results provide new insight into the design of more effective and selective imaging probes as well as drug carriers. |
| WOS关键词 | QUANTUM DOTS ; CELLULAR UPTAKE ; DRUG-DELIVERY ; LIVING CELLS ; LIVE CELLS ; NANOPARTICLES ; CYTOTOXICITY ; FLUORESCENCE ; TRANSDUCER ; INSIGHTS |
| 语种 | 英语 |
| WOS记录号 | WOS:000404807200017 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28795]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Han, YP,Li, XM,Chen, HB,et al. Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(25):21200-21208. |
| APA | Han, YP.,Li, XM.,Chen, HB.,Hu, XJ.,Luo, Y.,...&Chen, N.(2017).Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots.ACS APPLIED MATERIALS & INTERFACES,9(25),21200-21208. |
| MLA | Han, YP,et al."Real-Time Imaging of Endocytosis and Intracellular Trafficking of Semiconducting Polymer Dots".ACS APPLIED MATERIALS & INTERFACES 9.25(2017):21200-21208. |
入库方式： OAI收割
来源：上海应用物理研究所
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