Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking
文献类型：期刊论文
| 作者 | Zhang, KY; Feng, Q; Xu, JB; Xu, XY; Tian, F; Yeung, KWK; Bian, LM |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2017 |
| 卷号 | 27期号:34页码:- |
| 关键词 | Calcium-phosphate Nanoparticles In-situ Regenerative Medicine Osteogenic Differentiation Orthopedic Implants Tissue Regeneration Graphene Oxide Bone Hydroxyapatite Hyaluronan |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201701642 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Nanocomposite hydrogels consist of a polymer matrix embedded with nanoparticles (NPs), which provide the hydrogels with unique bioactivities and mechanical properties. Incorporation of NPs via in situ precipitation in the polymer matrix further enhances these desirable hydrogel properties. However, the noncytocompatible pH, osmolality, and lengthy duration typically required for such in situ precipitation strategies preclude cell encapsulation in the resultant hydrogels. Bisphosphonate (BP) exhibits a variety of specific bioactivities and excellent binding affinity to multivalent cations such as magnesium ions (Mg2+). Here, the preparation of nanocomposite hydrogels via self-assembly driven by bisphosphonate-Mg2+ coordination is described. Upon mixing solutions of polymer bearing BPs, BP monomer (Ac-BP), and Mg2+, this effective and dynamic coordination leads to the rapid self-assembly of Ac-BP-Mg NPs which function as multivalent crosslinkers stabilize the resultant hydrogel structure at physiological pH. The obtained nanocomposite hydrogels are self-healing and exhibit improved mechanical properties compared to hydrogels prepared by blending prefabricated NPs. Importantly, the hydrogels in this study allow the encapsulation of cells and subsequent injection without compromising the viability of seeded cells. Furthermore, the acrylate groups on the surface of Ac-BP-Mg NPs enable facile temporal control over the stiffness and crosslinking density of hydrogels via UV-induced secondary crosslinking, and it is found that the delayed introduction of this secondary crosslinking enhances cell spreading and osteogenesis. |
| WOS关键词 | CALCIUM-PHOSPHATE NANOPARTICLES ; IN-SITU ; REGENERATIVE MEDICINE ; OSTEOGENIC DIFFERENTIATION ; ORTHOPEDIC IMPLANTS ; TISSUE REGENERATION ; GRAPHENE OXIDE ; BONE ; HYDROXYAPATITE ; HYALURONAN |
| 语种 | 英语 |
| WOS记录号 | WOS:000410162200005 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28811]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhang, KY,Feng, Q,Xu, JB,et al. Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(34):-. |
| APA | Zhang, KY.,Feng, Q.,Xu, JB.,Xu, XY.,Tian, F.,...&Bian, LM.(2017).Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking.ADVANCED FUNCTIONAL MATERIALS,27(34),-. |
| MLA | Zhang, KY,et al."Self-Assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Dual Crosslinking".ADVANCED FUNCTIONAL MATERIALS 27.34(2017):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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