Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography
文献类型：期刊论文
| 作者 | Wang, LP; Mu, ZH; Lin, XJ; Geng, JL; Xiao, TQ; Zhang, ZJ; Wang, YT; Guan, YJ; Yang, GY |
| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
 |
| 出版日期 | 2017 |
| 卷号 | 9期号:-页码:- |
| 关键词 | Cerebral-artery Occlusion Blood-brain-barrier Magnetic-resonance Angiography Acute Ischemic-stroke In-vivo Collateral Circulation Mr-angiography Lifetime Risk Model Angiogenesis |
| ISSN号 | 1663-4365 |
| DOI | 10.3389/fnagi.2017.00359 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Hypertension has a profound influence on the structure and function of blood vessels. Cerebral vessels undergo both structural and functional changes in hypertensive animals. However, dynamic changes of cerebrovasculature and the factors involved in this process are largely unknown. In this study, we explored the dynamic changes of vascular structure in hypertensive rats using novel synchrotron radiation angiography. Twenty-four spontaneously hypertensive rats (SHR) and 24 Sprague-Dawley (SD) rats underwent synchrotron radiation (SR) angiography. Each group had 8 animals. We studied the cerebral vascular changes in SHR over a time period of 3-12-month and performed quantitative analysis. No vascular morphology differences between SHR and SD rats were observed in the early stage of hypertension. The number of twisted blood vessels in the front brain significantly increased at the 9-and 12-month observation time-points in the SHR compared to the SD rats (p < 0.01). The vessel density of the cortex and the striatum in SHR was consistently higher than that in SD rats at time points of 3-, 9-, and 12-month (p < 0.001). Vascular elasticity decreased both in SHR and SD rats with aging. There were statistically significant differences in the relative vascular elasticity of extracranial/intracranial internal carotid artery, middle cerebral artery, posterior cerebral artery and anterior cerebral artery between SHR and SD rats at 12-month (p < 0.01). We concluded that the dynamic vascular alterations detected by SR angiography provided novel imaging data for the study of hypertension in vivo. The longer the course of hypertension was, the more obvious the vascular differences between the SHR and the SD rats became. |
| WOS关键词 | CEREBRAL-ARTERY OCCLUSION ; BLOOD-BRAIN-BARRIER ; MAGNETIC-RESONANCE ANGIOGRAPHY ; ACUTE ISCHEMIC-STROKE ; IN-VIVO ; COLLATERAL CIRCULATION ; MR-ANGIOGRAPHY ; LIFETIME RISK ; MODEL ; ANGIOGENESIS |
| 语种 | 英语 |
| WOS记录号 | WOS:000414263300001 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28817]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wang, LP,Mu, ZH,Lin, XJ,et al. Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography[J]. FRONTIERS IN AGING NEUROSCIENCE,2017,9(-):-. |
| APA | Wang, LP.,Mu, ZH.,Lin, XJ.,Geng, JL.,Xiao, TQ.,...&Yang, GY.(2017).Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography.FRONTIERS IN AGING NEUROSCIENCE,9(-),-. |
| MLA | Wang, LP,et al."Simultaneous Imaging of Cerebrovascular Structure and Function in Hypertensive Rats Using Synchrotron Radiation Angiography".FRONTIERS IN AGING NEUROSCIENCE 9.-(2017):-. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。