Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes
文献类型：期刊论文
| 作者 | Liu, P; Zhao, Y; Liu, XG; Sun, JX; Xu, DD; Li, Y; Li, Q; Wang, LH; Yang, SC; Fan, CH |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2018 |
| 卷号 | 57期号:19页码:5418-5422 |
| ISSN号 | 1433-7851 |
| 关键词 | X-ray-scattering Origami Nanostructures Molecular-dynamics Crystal-structure Channel Membrane Transport Elasticity Mechanisms |
| DOI | 10.1002/anie.201801498 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Reconfiguration of membrane protein channels for gated transport is highly regulated under physiological conditions. However, a mechanistic understanding of such channels remains challenging owing to the difficulty in probing subtle gating-associated structural changes. Herein, we show that charge neutralization can drive the shape reconfiguration of a biomimetic 6-helix bundle DNA nanotube (6HB). Specifically, 6HB adopts a compact state when its charge is neutralized by Mg2+; whereas Na+ switches it to the expanded state, as revealed by MD simulations, small-angle X-ray scattering (SAXS), and FRET characterization. Furthermore, partial neutralization of the DNA backbone charges by chemical modification renders 6HB compact and insensitive to ions, suggesting an interplay between electrostatic and hydrophobic forces in the channels. This system provides a platform for understanding the structure-function relationship of biological channels and designing rules for the shape control of DNA nanostructures in biomedical applications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000431035500041 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28939]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Liu, P 2.Zhao, Y 3.Liu, XG 4.Sun, JX 5.Xu, DD 6.Li, Y 7.Li, Q 8.Wang, LH 9.Yang, SC 10.Fan, CH |
| 推荐引用方式 GB/T 7714 | Liu, P,Zhao, Y,Liu, XG,et al. Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(19):5418-5422. |
| APA | Liu, P.,Zhao, Y.,Liu, XG.,Sun, JX.,Xu, DD.,...&Lin, JP.(2018).Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(19),5418-5422. |
| MLA | Liu, P,et al."Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.19(2018):5418-5422. |
入库方式： OAI收割
来源：上海应用物理研究所
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