CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro
文献类型：期刊论文
| 作者 | Qian, TT; Liu, YC; Dong, Y; Zhang, L; Dong, YN; Sun, YH; Sun, DM |
| 刊名 | MOLECULAR MEDICINE REPORTS
 |
| 出版日期 | 2018 |
| 卷号 | 17期号:3页码:3633-3639 |
| 关键词 | Hepatocellular-carcinoma Cells Chemokine Receptor Cxcr7 Mesenchymal Stem-cells Prostate-cancer Growth Expression Lung Prognosis Migration Proliferation |
| ISSN号 | 1791-2997 |
| DOI | 10.3892/mmr.2017.8286 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The chemokine receptor CXCR7 is regarded as a scavenger receptor for CXCL12, and induces numerous key steps in tumor growth and metastasis. However, the exact molecular mechanism of CXCR7 regulation in breast tumor angiogenesis remains unknown. In the present study, the function of CXCR7 in breast tumors was investigated in vitro and in vivo. The breast cancer MDA-MB-231 cell line was used. Pharmacological inhibition of CXCR7 by CCX771 reduced breast tumor invasion, adhesion and metastasis. Furthermore, CXCR7 was essential for the tube formation of HUVECs in vitro, and for blood vessel formation in a Matrigel plug assay in vivo. In addition, vascular endothelial growth factor expression was also decreased in CCX771-treated MDA-MB-231 cells, indicating that CCX771 regulates tumor angiogenesis. The present results indicated that CXCR7 regulated breast cancer metastasis at multiple stages; additional understanding of CXCR7 in tumor environments may develop anti-metastatic therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000424400000025 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/28955]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Qian, TT 2.Liu, YC 3.Dong, Y 4.Zhang, L 5.Dong, YN 6.Sun, YH 7.Sun, DM |
| 推荐引用方式 GB/T 7714 | Qian, TT,Liu, YC,Dong, Y,et al. CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro[J]. MOLECULAR MEDICINE REPORTS,2018,17(3):3633-3639. |
| APA | Qian, TT.,Liu, YC.,Dong, Y.,Zhang, L.,Dong, YN.,...&Sun, DM.(2018).CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro.MOLECULAR MEDICINE REPORTS,17(3),3633-3639. |
| MLA | Qian, TT,et al."CXCR7 regulates breast tumor metastasis and angiogenesis in vivo and in vitro".MOLECULAR MEDICINE REPORTS 17.3(2018):3633-3639. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。